A mechanism for epigenetic control of DNA replication

DNA replication origins in hyperacetylated euchromatin fire preferentially during early S phase. However, how acetylation controls DNA replication timing is unknown. TICRR/TRESLIN is an essential protein required for the initiation of DNA replication. Here, we report that TICRR physically interacts...

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Detalles Bibliográficos
Autores principales: Sansam, Courtney G., Pietrzak, Katarzyna, Majchrzycka, Blanka, Kerlin, Maciej A., Chen, Jingrong, Rankin, Susannah, Sansam, Christopher L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859964/
https://www.ncbi.nlm.nih.gov/pubmed/29483155
http://dx.doi.org/10.1101/gad.306464.117
Descripción
Sumario:DNA replication origins in hyperacetylated euchromatin fire preferentially during early S phase. However, how acetylation controls DNA replication timing is unknown. TICRR/TRESLIN is an essential protein required for the initiation of DNA replication. Here, we report that TICRR physically interacts with the acetyl-histone binding bromodomain (BRD) and extraterminal (BET) proteins BRD2 and BRD4. Abrogation of this interaction impairs TICRR binding to acetylated chromatin and disrupts normal S-phase progression. Our data reveal a novel function for BET proteins and establish the TICRR–BET interaction as a potential mechanism for epigenetic control of DNA replication.

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