A mechanism for epigenetic control of DNA replication

DNA replication origins in hyperacetylated euchromatin fire preferentially during early S phase. However, how acetylation controls DNA replication timing is unknown. TICRR/TRESLIN is an essential protein required for the initiation of DNA replication. Here, we report that TICRR physically interacts...

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Detalles Bibliográficos
Autores principales: Sansam, Courtney G., Pietrzak, Katarzyna, Majchrzycka, Blanka, Kerlin, Maciej A., Chen, Jingrong, Rankin, Susannah, Sansam, Christopher L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859964/
https://www.ncbi.nlm.nih.gov/pubmed/29483155
http://dx.doi.org/10.1101/gad.306464.117
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author Sansam, Courtney G.
Pietrzak, Katarzyna
Majchrzycka, Blanka
Kerlin, Maciej A.
Chen, Jingrong
Rankin, Susannah
Sansam, Christopher L.
author_facet Sansam, Courtney G.
Pietrzak, Katarzyna
Majchrzycka, Blanka
Kerlin, Maciej A.
Chen, Jingrong
Rankin, Susannah
Sansam, Christopher L.
author_sort Sansam, Courtney G.
collection PubMed
description DNA replication origins in hyperacetylated euchromatin fire preferentially during early S phase. However, how acetylation controls DNA replication timing is unknown. TICRR/TRESLIN is an essential protein required for the initiation of DNA replication. Here, we report that TICRR physically interacts with the acetyl-histone binding bromodomain (BRD) and extraterminal (BET) proteins BRD2 and BRD4. Abrogation of this interaction impairs TICRR binding to acetylated chromatin and disrupts normal S-phase progression. Our data reveal a novel function for BET proteins and establish the TICRR–BET interaction as a potential mechanism for epigenetic control of DNA replication.
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spelling pubmed-58599642018-08-01 A mechanism for epigenetic control of DNA replication Sansam, Courtney G. Pietrzak, Katarzyna Majchrzycka, Blanka Kerlin, Maciej A. Chen, Jingrong Rankin, Susannah Sansam, Christopher L. Genes Dev Research Communication DNA replication origins in hyperacetylated euchromatin fire preferentially during early S phase. However, how acetylation controls DNA replication timing is unknown. TICRR/TRESLIN is an essential protein required for the initiation of DNA replication. Here, we report that TICRR physically interacts with the acetyl-histone binding bromodomain (BRD) and extraterminal (BET) proteins BRD2 and BRD4. Abrogation of this interaction impairs TICRR binding to acetylated chromatin and disrupts normal S-phase progression. Our data reveal a novel function for BET proteins and establish the TICRR–BET interaction as a potential mechanism for epigenetic control of DNA replication. Cold Spring Harbor Laboratory Press 2018-02-01 /pmc/articles/PMC5859964/ /pubmed/29483155 http://dx.doi.org/10.1101/gad.306464.117 Text en © 2018 Sansam et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research Communication
Sansam, Courtney G.
Pietrzak, Katarzyna
Majchrzycka, Blanka
Kerlin, Maciej A.
Chen, Jingrong
Rankin, Susannah
Sansam, Christopher L.
A mechanism for epigenetic control of DNA replication
title A mechanism for epigenetic control of DNA replication
title_full A mechanism for epigenetic control of DNA replication
title_fullStr A mechanism for epigenetic control of DNA replication
title_full_unstemmed A mechanism for epigenetic control of DNA replication
title_short A mechanism for epigenetic control of DNA replication
title_sort mechanism for epigenetic control of dna replication
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859964/
https://www.ncbi.nlm.nih.gov/pubmed/29483155
http://dx.doi.org/10.1101/gad.306464.117
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