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Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans
Tissue–tissue communications are integral to organismal aging, orchestrating a body-wide aging process. The brain plays a key role in this process by detecting and processing signals from the environment and then communicating them to distal tissues such as the gut to regulate longevity. How this is...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859967/ https://www.ncbi.nlm.nih.gov/pubmed/29491136 http://dx.doi.org/10.1101/gad.309625.117 |
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author | Zhang, Bi Gong, Jianke Zhang, Wenyuan Xiao, Rui Liu, Jianfeng Xu, X.Z. Shawn |
author_facet | Zhang, Bi Gong, Jianke Zhang, Wenyuan Xiao, Rui Liu, Jianfeng Xu, X.Z. Shawn |
author_sort | Zhang, Bi |
collection | PubMed |
description | Tissue–tissue communications are integral to organismal aging, orchestrating a body-wide aging process. The brain plays a key role in this process by detecting and processing signals from the environment and then communicating them to distal tissues such as the gut to regulate longevity. How this is achieved, however, is poorly understood. Here, using Caenorhabditis elegans as a model, we identified two distinct neuroendocrine signaling circuits by which the worm nervous system senses cool and warm environmental temperatures through cool- and warm-sensitive neurons and then signals the gut to extend and shorten life span, respectively. The prolongevity “cool” circuit uses the small neurotransmitters glutamate and serotonin, whereas the anti-longevity “warm” circuit is mediated by insulin-like neuropeptides. Both types of neuroendocrine signals converge on the gut through their cognate receptors to differentially regulate the transcription factor DAF-16/FOXO, leading to opposing outcomes in longevity. Our study illustrates how the brain detects and processes environmental signals to bidirectionally regulate longevity by signaling the gut. |
format | Online Article Text |
id | pubmed-5859967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58599672018-08-01 Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans Zhang, Bi Gong, Jianke Zhang, Wenyuan Xiao, Rui Liu, Jianfeng Xu, X.Z. Shawn Genes Dev Research Paper Tissue–tissue communications are integral to organismal aging, orchestrating a body-wide aging process. The brain plays a key role in this process by detecting and processing signals from the environment and then communicating them to distal tissues such as the gut to regulate longevity. How this is achieved, however, is poorly understood. Here, using Caenorhabditis elegans as a model, we identified two distinct neuroendocrine signaling circuits by which the worm nervous system senses cool and warm environmental temperatures through cool- and warm-sensitive neurons and then signals the gut to extend and shorten life span, respectively. The prolongevity “cool” circuit uses the small neurotransmitters glutamate and serotonin, whereas the anti-longevity “warm” circuit is mediated by insulin-like neuropeptides. Both types of neuroendocrine signals converge on the gut through their cognate receptors to differentially regulate the transcription factor DAF-16/FOXO, leading to opposing outcomes in longevity. Our study illustrates how the brain detects and processes environmental signals to bidirectionally regulate longevity by signaling the gut. Cold Spring Harbor Laboratory Press 2018-02-01 /pmc/articles/PMC5859967/ /pubmed/29491136 http://dx.doi.org/10.1101/gad.309625.117 Text en © 2018 Zhang et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Paper Zhang, Bi Gong, Jianke Zhang, Wenyuan Xiao, Rui Liu, Jianfeng Xu, X.Z. Shawn Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans |
title | Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans |
title_full | Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans |
title_fullStr | Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans |
title_full_unstemmed | Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans |
title_short | Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans |
title_sort | brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in c. elegans |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859967/ https://www.ncbi.nlm.nih.gov/pubmed/29491136 http://dx.doi.org/10.1101/gad.309625.117 |
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