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Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans

Tissue–tissue communications are integral to organismal aging, orchestrating a body-wide aging process. The brain plays a key role in this process by detecting and processing signals from the environment and then communicating them to distal tissues such as the gut to regulate longevity. How this is...

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Autores principales: Zhang, Bi, Gong, Jianke, Zhang, Wenyuan, Xiao, Rui, Liu, Jianfeng, Xu, X.Z. Shawn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859967/
https://www.ncbi.nlm.nih.gov/pubmed/29491136
http://dx.doi.org/10.1101/gad.309625.117
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author Zhang, Bi
Gong, Jianke
Zhang, Wenyuan
Xiao, Rui
Liu, Jianfeng
Xu, X.Z. Shawn
author_facet Zhang, Bi
Gong, Jianke
Zhang, Wenyuan
Xiao, Rui
Liu, Jianfeng
Xu, X.Z. Shawn
author_sort Zhang, Bi
collection PubMed
description Tissue–tissue communications are integral to organismal aging, orchestrating a body-wide aging process. The brain plays a key role in this process by detecting and processing signals from the environment and then communicating them to distal tissues such as the gut to regulate longevity. How this is achieved, however, is poorly understood. Here, using Caenorhabditis elegans as a model, we identified two distinct neuroendocrine signaling circuits by which the worm nervous system senses cool and warm environmental temperatures through cool- and warm-sensitive neurons and then signals the gut to extend and shorten life span, respectively. The prolongevity “cool” circuit uses the small neurotransmitters glutamate and serotonin, whereas the anti-longevity “warm” circuit is mediated by insulin-like neuropeptides. Both types of neuroendocrine signals converge on the gut through their cognate receptors to differentially regulate the transcription factor DAF-16/FOXO, leading to opposing outcomes in longevity. Our study illustrates how the brain detects and processes environmental signals to bidirectionally regulate longevity by signaling the gut.
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spelling pubmed-58599672018-08-01 Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans Zhang, Bi Gong, Jianke Zhang, Wenyuan Xiao, Rui Liu, Jianfeng Xu, X.Z. Shawn Genes Dev Research Paper Tissue–tissue communications are integral to organismal aging, orchestrating a body-wide aging process. The brain plays a key role in this process by detecting and processing signals from the environment and then communicating them to distal tissues such as the gut to regulate longevity. How this is achieved, however, is poorly understood. Here, using Caenorhabditis elegans as a model, we identified two distinct neuroendocrine signaling circuits by which the worm nervous system senses cool and warm environmental temperatures through cool- and warm-sensitive neurons and then signals the gut to extend and shorten life span, respectively. The prolongevity “cool” circuit uses the small neurotransmitters glutamate and serotonin, whereas the anti-longevity “warm” circuit is mediated by insulin-like neuropeptides. Both types of neuroendocrine signals converge on the gut through their cognate receptors to differentially regulate the transcription factor DAF-16/FOXO, leading to opposing outcomes in longevity. Our study illustrates how the brain detects and processes environmental signals to bidirectionally regulate longevity by signaling the gut. Cold Spring Harbor Laboratory Press 2018-02-01 /pmc/articles/PMC5859967/ /pubmed/29491136 http://dx.doi.org/10.1101/gad.309625.117 Text en © 2018 Zhang et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research Paper
Zhang, Bi
Gong, Jianke
Zhang, Wenyuan
Xiao, Rui
Liu, Jianfeng
Xu, X.Z. Shawn
Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans
title Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans
title_full Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans
title_fullStr Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans
title_full_unstemmed Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans
title_short Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans
title_sort brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in c. elegans
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859967/
https://www.ncbi.nlm.nih.gov/pubmed/29491136
http://dx.doi.org/10.1101/gad.309625.117
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