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Transcription elongation rate affects nascent histone pre-mRNA folding and 3′ end processing

Transcription elongation rate influences cotranscriptional pre-mRNA maturation, but how such kinetic coupling works is poorly understood. The formation of nonadenylated histone mRNA 3′ ends requires recognition of an RNA structure by stem–loop-binding protein (SLBP). We report that slow transcriptio...

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Detalles Bibliográficos
Autores principales: Saldi, Tassa, Fong, Nova, Bentley, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859970/
https://www.ncbi.nlm.nih.gov/pubmed/29483154
http://dx.doi.org/10.1101/gad.310896.117