The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

Somatic mutations in spliceosome proteins lead to dysregulated RNA splicing and are observed in a variety of cancers. These genetic aberrations may offer a potential intervention point for targeted therapeutics. SF3B1, part of the U2 small nuclear RNP (snRNP), is targeted by splicing modulators, inc...

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Detalles Bibliográficos
Autores principales: Finci, Lorenzo I., Zhang, Xiaofeng, Huang, Xiuliang, Zhou, Qiang, Tsai, Jennifer, Teng, Teng, Agrawal, Anant, Chan, Betty, Irwin, Sean, Karr, Craig, Cook, Andrew, Zhu, Ping, Reynolds, Dominic, Smith, Peter G., Fekkes, Peter, Buonamici, Silvia, Larsen, Nicholas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859971/
https://www.ncbi.nlm.nih.gov/pubmed/29491137
http://dx.doi.org/10.1101/gad.311043.117

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