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AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans
Feeding behavior is the most fundamental behavior in C. elegans. Our previous results have dissected the central integration circuit for the regulation of feeding, which integrates opposing sensory inputs and regulates feeding behavior in a nonlinear manner. However, the peripheral integration that...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860128/ https://www.ncbi.nlm.nih.gov/pubmed/29577066 http://dx.doi.org/10.1007/s41048-018-0046-2 |
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author | Fu, Jiajun Zhang, Haining Huang, Wenming Zhu, Xinyu Sheng, Yi Song, Eli Xu, Tao |
author_facet | Fu, Jiajun Zhang, Haining Huang, Wenming Zhu, Xinyu Sheng, Yi Song, Eli Xu, Tao |
author_sort | Fu, Jiajun |
collection | PubMed |
description | Feeding behavior is the most fundamental behavior in C. elegans. Our previous results have dissected the central integration circuit for the regulation of feeding, which integrates opposing sensory inputs and regulates feeding behavior in a nonlinear manner. However, the peripheral integration that acts downstream of the central integration circuit to modulate feeding remains largely unknown. Here, we find that a Gαi/o-coupled tyramine receptor, TYRA-2, is involved in peripheral feeding suppression. TYRA-2 suppresses feeding behavior via the AIM interneurons, which receive tyramine/octopamine signals from RIM/RIC neurons in the central integration circuit. Our results reveal previously unidentified roles for the receptor TYRA-2 and the AIM interneurons in feeding regulation, providing a further understanding of how biogenic amines tyramine and octopamine regulate feeding behavior. |
format | Online Article Text |
id | pubmed-5860128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-58601282018-03-22 AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans Fu, Jiajun Zhang, Haining Huang, Wenming Zhu, Xinyu Sheng, Yi Song, Eli Xu, Tao Biophys Rep Research Article Feeding behavior is the most fundamental behavior in C. elegans. Our previous results have dissected the central integration circuit for the regulation of feeding, which integrates opposing sensory inputs and regulates feeding behavior in a nonlinear manner. However, the peripheral integration that acts downstream of the central integration circuit to modulate feeding remains largely unknown. Here, we find that a Gαi/o-coupled tyramine receptor, TYRA-2, is involved in peripheral feeding suppression. TYRA-2 suppresses feeding behavior via the AIM interneurons, which receive tyramine/octopamine signals from RIM/RIC neurons in the central integration circuit. Our results reveal previously unidentified roles for the receptor TYRA-2 and the AIM interneurons in feeding regulation, providing a further understanding of how biogenic amines tyramine and octopamine regulate feeding behavior. Springer Berlin Heidelberg 2018-03-05 2018 /pmc/articles/PMC5860128/ /pubmed/29577066 http://dx.doi.org/10.1007/s41048-018-0046-2 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Article Fu, Jiajun Zhang, Haining Huang, Wenming Zhu, Xinyu Sheng, Yi Song, Eli Xu, Tao AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans |
title | AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans |
title_full | AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans |
title_fullStr | AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans |
title_full_unstemmed | AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans |
title_short | AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans |
title_sort | aim interneurons mediate feeding suppression through the tyra-2 receptor in c. elegans |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860128/ https://www.ncbi.nlm.nih.gov/pubmed/29577066 http://dx.doi.org/10.1007/s41048-018-0046-2 |
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