β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation

GPR119 was originally identified as an orphan β-cell receptor; however, subsequent studies demonstrated that GPR119 also regulates β-cell function indirectly through incretin hormone secretion. We assessed the importance of GPR119 for β-cell function in Gpr119(−/−) mice and in newly generated Gpr119...

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Detalles Bibliográficos
Autores principales: Panaro, Brandon L., Flock, Grace B., Campbell, Jonathan E., Beaudry, Jacqueline L., Cao, Xiemin, Drucker, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860191/
https://www.ncbi.nlm.nih.gov/pubmed/28254842
http://dx.doi.org/10.2337/db17-0017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860191/
https://www.ncbi.nlm.nih.gov/pubmed/28254842
http://dx.doi.org/10.2337/db17-0017

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