Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway

Beiging of white adipose tissue has potential antiobesity and antidiabetes effects, yet the underlying signaling mechanisms remain to be fully elucidated. Here we show that adipose-specific knockout of Rheb, an upstream activator of mechanistic target of rapamycin complex 1 (mTORC1), protects mice f...

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Detalles Bibliográficos
Autores principales: Meng, Wen, Liang, Xiuci, Chen, Hongzhi, Luo, Hairong, Bai, Juli, Li, Guangdi, Zhang, Qinghai, Xiao, Ting, He, Sijia, Zhang, Yacheng, Xu, Zhipeng, Xiao, Bo, Liu, Meilian, Hu, Fang, Liu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860267/
https://www.ncbi.nlm.nih.gov/pubmed/28242620
http://dx.doi.org/10.2337/db16-0886

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