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Efficient inference for sparse latent variable models of transcriptional regulation

MOTIVATION: Regulation of gene expression in prokaryotes involves complex co-regulatory mechanisms involving large numbers of transcriptional regulatory proteins and their target genes. Uncovering these genome-scale interactions constitutes a major bottleneck in systems biology. Sparse latent factor...

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Detalles Bibliográficos
Autores principales:	Dai, Zhenwen, Iqbal, Mudassar, Lawrence, Neil D, Rattray, Magnus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860323/ https://www.ncbi.nlm.nih.gov/pubmed/28961802 http://dx.doi.org/10.1093/bioinformatics/btx508

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