Cargando…

Associations of Leukocyte Telomere Length With Aerobic and Muscular Fitness in Young Adults

Decline in both telomere length and physical fitness over the life course may contribute to increased risk of several chronic diseases. The relationship between telomere length and aerobic and muscular fitness is not well characterized. We examined whether there are cross-sectional associations of m...

Descripción completa

Detalles Bibliográficos
Autores principales: Williams, Dylan M., Buxton, Jessica L., Kantomaa, Marko T., Tammelin, Tuija H., Blakemore, Alexandra I. F., Järvelin, Marjo-Riitta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860435/
https://www.ncbi.nlm.nih.gov/pubmed/28338837
http://dx.doi.org/10.1093/aje/kww123
_version_ 1783307973654740992
author Williams, Dylan M.
Buxton, Jessica L.
Kantomaa, Marko T.
Tammelin, Tuija H.
Blakemore, Alexandra I. F.
Järvelin, Marjo-Riitta
author_facet Williams, Dylan M.
Buxton, Jessica L.
Kantomaa, Marko T.
Tammelin, Tuija H.
Blakemore, Alexandra I. F.
Järvelin, Marjo-Riitta
author_sort Williams, Dylan M.
collection PubMed
description Decline in both telomere length and physical fitness over the life course may contribute to increased risk of several chronic diseases. The relationship between telomere length and aerobic and muscular fitness is not well characterized. We examined whether there are cross-sectional associations of mean relative leukocyte telomere length (LTL) with objective measures of aerobic fitness, muscle strength, and muscle endurance, using data on 31-year-old participants of the Northern Finland Birth Cohort 1966 (n = 4,952–5,205, varying by exposure-outcome analysis). Aerobic fitness was assessed by means of heart rate measurement following a standardized submaximal step test; muscular fitness was assessed by means of a maximal isometric handgrip strength test and a test of lower-back trunk muscle endurance. Longer LTL was associated with higher aerobic fitness and better trunk muscle endurance in models including adjustment for age, sex, body mass index, socioeconomic position, diet, smoking, alcohol consumption, physical activity level, and C-reactive protein. In a sex-stratified analysis, LTL was not associated with handgrip strength in either men or women. LTL may relate to aspects of physical fitness in young adulthood, but replication of these findings is required, along with further studies to help assess directions and causality in these associations.
format Online
Article
Text
id pubmed-5860435
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-58604352018-03-28 Associations of Leukocyte Telomere Length With Aerobic and Muscular Fitness in Young Adults Williams, Dylan M. Buxton, Jessica L. Kantomaa, Marko T. Tammelin, Tuija H. Blakemore, Alexandra I. F. Järvelin, Marjo-Riitta Am J Epidemiol Original Contributions Decline in both telomere length and physical fitness over the life course may contribute to increased risk of several chronic diseases. The relationship between telomere length and aerobic and muscular fitness is not well characterized. We examined whether there are cross-sectional associations of mean relative leukocyte telomere length (LTL) with objective measures of aerobic fitness, muscle strength, and muscle endurance, using data on 31-year-old participants of the Northern Finland Birth Cohort 1966 (n = 4,952–5,205, varying by exposure-outcome analysis). Aerobic fitness was assessed by means of heart rate measurement following a standardized submaximal step test; muscular fitness was assessed by means of a maximal isometric handgrip strength test and a test of lower-back trunk muscle endurance. Longer LTL was associated with higher aerobic fitness and better trunk muscle endurance in models including adjustment for age, sex, body mass index, socioeconomic position, diet, smoking, alcohol consumption, physical activity level, and C-reactive protein. In a sex-stratified analysis, LTL was not associated with handgrip strength in either men or women. LTL may relate to aspects of physical fitness in young adulthood, but replication of these findings is required, along with further studies to help assess directions and causality in these associations. Oxford University Press 2017-04-01 2017-03-01 /pmc/articles/PMC5860435/ /pubmed/28338837 http://dx.doi.org/10.1093/aje/kww123 Text en © The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0 (http://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Contributions
Williams, Dylan M.
Buxton, Jessica L.
Kantomaa, Marko T.
Tammelin, Tuija H.
Blakemore, Alexandra I. F.
Järvelin, Marjo-Riitta
Associations of Leukocyte Telomere Length With Aerobic and Muscular Fitness in Young Adults
title Associations of Leukocyte Telomere Length With Aerobic and Muscular Fitness in Young Adults
title_full Associations of Leukocyte Telomere Length With Aerobic and Muscular Fitness in Young Adults
title_fullStr Associations of Leukocyte Telomere Length With Aerobic and Muscular Fitness in Young Adults
title_full_unstemmed Associations of Leukocyte Telomere Length With Aerobic and Muscular Fitness in Young Adults
title_short Associations of Leukocyte Telomere Length With Aerobic and Muscular Fitness in Young Adults
title_sort associations of leukocyte telomere length with aerobic and muscular fitness in young adults
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860435/
https://www.ncbi.nlm.nih.gov/pubmed/28338837
http://dx.doi.org/10.1093/aje/kww123
work_keys_str_mv AT williamsdylanm associationsofleukocytetelomerelengthwithaerobicandmuscularfitnessinyoungadults
AT buxtonjessical associationsofleukocytetelomerelengthwithaerobicandmuscularfitnessinyoungadults
AT kantomaamarkot associationsofleukocytetelomerelengthwithaerobicandmuscularfitnessinyoungadults
AT tammelintuijah associationsofleukocytetelomerelengthwithaerobicandmuscularfitnessinyoungadults
AT blakemorealexandraif associationsofleukocytetelomerelengthwithaerobicandmuscularfitnessinyoungadults
AT jarvelinmarjoriitta associationsofleukocytetelomerelengthwithaerobicandmuscularfitnessinyoungadults