SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements

Mms21, a subunit of the Smc5/6 complex, possesses an E3 ligase activity for the Small Ubiquitin-like MOdifier (SUMO). Here we show that the mms21-CH mutation, which inactivates Mms21 ligase activity, causes increased accumulation of gross chromosomal rearrangements (GCRs) selected in the dGCR assay....

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Detalles Bibliográficos
Autores principales: Liang, Jason, Li, Bin-zhong, Tan, Alexander P., Kolodner, Richard D., Putnam, Christopher D., Zhou, Huilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860785/
https://www.ncbi.nlm.nih.gov/pubmed/29505562
http://dx.doi.org/10.1371/journal.pgen.1007250

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