Cargando…

New Understanding of β-Cell Heterogeneity and In Situ Islet Function

Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While long known, recent technological advances and new markers have allowed the identification of novel subpopulations, improving our understanding of the molecular basis for heterogeneity. This includes specific su...

Descripción completa

Detalles Bibliográficos
Autores principales:	Benninger, Richard K.P., Hodson, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2018
Materias:	Perspectives in Diabetes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860861/ https://www.ncbi.nlm.nih.gov/pubmed/29559510 http://dx.doi.org/10.2337/dbi17-0040

Ejemplares similares

Current Advances and Travails in Islet Transplantation
por: Harlan, David M., et al.
Publicado: (2009)

Clinical Islet Xenotransplantation: How Close Are We?
por: van der Windt, Dirk J., et al.
Publicado: (2012)

Etiology of Autoimmune Islet Disease: Timing Is Everything
por: Lernmark, Åke
Publicado: (2021)

Navigating the Depths and Avoiding the Shallows of Pancreatic Islet Cell Transcriptomes
por: Mawla, Alex M., et al.
Publicado: (2019)

The Immunoreactive Platform of the Pancreatic Islets Influences the Development of Autoreactivity
por: Unanue, Emil R., et al.
Publicado: (2019)

Islets in Type 2 Diabetes: In Honor of Dr. Robert C. Turner
por: Bonner-Weir, Susan, et al.
Publicado: (2008)

Toward Engineering a Novel Transplantation Site for Human Pancreatic Islets
por: Smink, Alexandra M., et al.
Publicado: (2013)

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis
por: Benninger, Richard K. P., et al.
Publicado: (2018)

Islet Transplantation a Decade Later and Strategies for Filling a Half-Full Glass
por: Robertson, R. Paul
Publicado: (2010)

The role of beta cell heterogeneity in islet function and insulin release
por: Nasteska, Daniela, et al.
Publicado: (2018)

Through the Fog: Recent Clinical Trials to Preserve β-Cell Function in Type 1 Diabetes
por: Greenbaum, Carla J., et al.
Publicado: (2012)

Dynamic changes in β-cell [Ca(2+)] regulate NFAT activation, gene transcription, and islet gap junction communication
por: Miranda, Jose G., et al.
Publicado: (2021)

Historical Perspective: Beginnings of the β-Cell: Current Perspectives in β-Cell Development
por: Seymour, Philip A., et al.
Publicado: (2011)

Is the Diminished Incretin Effect in Type 2 Diabetes Just an Epi-Phenomenon of Impaired β-Cell Function?
por: Meier, Juris J., et al.
Publicado: (2010)

Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes
por: Schmitz-Peiffer, Carsten, et al.
Publicado: (2008)

β-Cell MicroRNAs: Small but Powerful
por: Filios, Stephen R., et al.
Publicado: (2015)

Probing β-Cell Biology in Space and Time
por: Arrojo e Drigo, Rafael
Publicado: (2021)

Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention
por: Charles, M. Arthur, et al.
Publicado: (2021)

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth
por: Hang, Yan, et al.
Publicado: (2014)

β-Cell Growth and Regeneration: Replication Is Only Part of the Story
por: Bonner-Weir, Susan, et al.
Publicado: (2010)

Human β-Cell Proliferation and Intracellular Signaling: Part 3
por: Stewart, Andrew F., et al.
Publicado: (2015)

Conflicting Views About Interactions Between Pancreatic α-Cells and β-Cells
por: Weir, Gordon C., et al.
Publicado: (2023)

Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance
por: James, Eddie A., et al.
Publicado: (2018)

β-Cell Mass and Type 1 Diabetes: Going, Going, Gone?
por: Akirav, Eitan, et al.
Publicado: (2008)

MicroRNAs in β-Cell Biology, Insulin Resistance, Diabetes and Its Complications
por: Fernandez-Valverde, Selene L., et al.
Publicado: (2011)

Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense?
por: Rhodes, Christopher J., et al.
Publicado: (2013)

Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic β-Cells
por: Sharma, Rohit B., et al.
Publicado: (2021)

Human β-Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map
por: Bernal-Mizrachi, Ernesto, et al.
Publicado: (2014)

Toward a More Complete (and Less Controversial) Understanding of Energy Expenditure and Its Role in Obesity Pathogenesis
por: Kaiyala, Karl J., et al.
Publicado: (2011)

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes
por: Eizirik, Decio L., et al.
Publicado: (2021)

How Does Type 1 Diabetes Develop?: The Notion of Homicide or β-Cell Suicide Revisited
por: Atkinson, Mark A., et al.
Publicado: (2011)

Human β-Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map
por: Kulkarni, Rohit N., et al.
Publicado: (2012)

β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion?
por: Schuit, Frans, et al.
Publicado: (2012)

β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?
por: Costes, Safia, et al.
Publicado: (2013)

COVID-19–Induced New-Onset Diabetes: Trends and Technologies
por: Metwally, Ahmed A., et al.
Publicado: (2021)

Understanding the Role of Surface Heterogeneities in Electrosynthesis Reactions
por: Carvalho, O. Quinn, et al.
Publicado: (2020)

Bridging the Gap in the Mechanistic Understanding of Electrocatalysis via In Situ Characterizations
por: Malkani, Arnav S., et al.
Publicado: (2020)

Functional Implications of DNA Methylation in Adipose Biology
por: Ma, Xiang, et al.
Publicado: (2019)

Insulin Regulates Brain Function, but How Does It Get There?
por: Gray, Sarah M., et al.
Publicado: (2014)

Function and Mechanism of Long Noncoding RNAs in Adipocyte Biology
por: Sun, Lei, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6n5ll3nrt013hups6722ev4dmk