Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir

Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus reservoir hosts. The dengue virus 2 (DENV2) - encoded protease cleaves human STING, reducing typ...

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Detalles Bibliográficos
Autores principales: Stabell, Alex C, Meyerson, Nicholas R, Gullberg, Rebekah C, Gilchrist, Alison R, Webb, Kristofor J, Old, William M, Perera, Rushika, Sawyer, Sara L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860865/
https://www.ncbi.nlm.nih.gov/pubmed/29557779
http://dx.doi.org/10.7554/eLife.31919

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