Cargando…

SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation

Glycogen synthase kinase 3 (GSK3) is a critical regulator of diverse cellular functions involved in the maintenance of structure and function. Enzymatic activity of GSK3 is inhibited by N-terminal serine phosphorylation. However, alternate post-translational mechanism(s) responsible for GSK3 inactiv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sarikhani, Mohsen, Mishra, Sneha, Maity, Sangeeta, Kotyada, Chaithanya, Wolfgeher, Donald, Gupta, Mahesh P, Singh, Mahavir, Sundaresan, Nagalingam R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860870/ https://www.ncbi.nlm.nih.gov/pubmed/29504933 http://dx.doi.org/10.7554/eLife.32952

Ejemplares similares

SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity
por: Ravi, Venkatraman, et al.
Publicado: (2019)

Salmonella escapes adaptive immune response via SIRT2 mediated modulation of innate immune response in dendritic cells
por: Gogoi, Mayuri, et al.
Publicado: (2018)

Correction: Salmonella escapes adaptive immune response via SIRT2 mediated modulation of innate immune response in dendritic cells
por: Gogoi, Mayuri, et al.
Publicado: (2020)

Mechanistic Insights into the Differential Catalysis by RheB and Its Mutants: Y35A and Y35A-D65A
por: Kotyada, Chaithanya, et al.
Publicado: (2017)

Emerging Roles of SIRT3 in Cardiac Metabolism
por: Murugasamy, Krishnega, et al.
Publicado: (2022)

Diabetes induces fibrotic changes in the lung through the activation of TGF-β signaling pathways
por: Talakatta, Girish, et al.
Publicado: (2018)

Subcutaneous Ehrlich Ascites Carcinoma mice model for studying cancer-induced cardiomyopathy
por: Mishra, Sneha, et al.
Publicado: (2018)

SIRT3 deacetylase activity confers chemoresistance in AML via regulation of mitochondrial oxidative phosphorylation
por: Ma, Jiao, et al.
Publicado: (2019)

GSK-3β phosphorylation of functionally distinct tau isoforms has differential, but mild effects
por: Voss, Kellen, et al.
Publicado: (2009)

Inhibition of SIRT2 by Targeting GSK3β-Mediated Phosphorylation Alleviates SIRT2 Toxicity in SH-SY5Y Cells
por: Liu, Shuhu, et al.
Publicado: (2019)

The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy
por: Samant, Sadhana A., et al.
Publicado: (2017)

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial SIRT3
por: Pillai, Vinodkumar B., et al.
Publicado: (2015)

Glycogen Synthase Kinase-3 Isoform Variants and Their Inhibitory Phosphorylation in Human Testes and Spermatozoa
por: Park, Seung Hyun, et al.
Publicado: (2023)

SIRT6 exhibits nucleosome-dependent deacetylase activity
por: Gil, Reuven, et al.
Publicado: (2013)

Suppression of HTLV-1 transcription by SIRT1 deacetylase
por: Jin, Dong-Yan, et al.
Publicado: (2015)

Mitochondrial deacetylase Sirt3 in vascular dysfunction and hypertension
por: Dikalov, Sergey, et al.
Publicado: (2022)

Antagonistic role of GSK3 isoforms in glioma survival
por: Vashishtha, Vidhi, et al.
Publicado: (2018)

SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ
por: Khan, Danish, et al.
Publicado: (2021)

Histone Deacetylases and Their Isoform-Specific Inhibitors in Ischemic Stroke
por: Demyanenko, Svetlana, et al.
Publicado: (2021)

Proteogenomic Analysis of Breast Cancer Transcriptomic and Proteomic Data, Using De Novo Transcript Assembly: Genome-Wide Identification of Novel Peptides and Clinical Implications
por: Hari, P.S., et al.
Publicado: (2022)

EFFECT OF L-VALINE TREATMENT ON SIRTUIN (SIRT1 AND SIRT2) ISOFORMS
por: Sharma, Shakshi, et al.
Publicado: (2022)

Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase
por: Troelsen, Kathrin S., et al.
Publicado: (2021)

Discrete functions of GSK3α and GSK3β isoforms in prostate tumor growth and micrometastasis
por: Gao, Fei, et al.
Publicado: (2015)

Tau Phosphorylation by GSK3 in Different Conditions
por: Avila, Jesús, et al.
Publicado: (2012)

GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation
por: Gozdz, Agata, et al.
Publicado: (2017)

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
por: Firestein, Ron, et al.
Publicado: (2008)

The histone deacetylase SIRT6, a critical modulator of metabolism and tumorigenesis
por: Sebastian, Carlos, et al.
Publicado: (2012)

CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1
por: Hu, Xuebin, et al.
Publicado: (2018)

Nitro-fatty acids as activators of hSIRT6 deacetylase activity
por: Carreño, Mara, et al.
Publicado: (2021)

Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis
por: Moore, Samantha F., et al.
Publicado: (2021)

Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation
por: Amaral, Ana Claudia, et al.
Publicado: (2021)

Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7
por: Wu, Di, et al.
Publicado: (2018)

Phosphorylation Regulates SIRT1 Function
por: Sasaki, Tsutomu, et al.
Publicado: (2008)

Dataset of Nematostella vectensis Hsp70 isoform interactomes upon heat shock
por: Knighton, Laura E., et al.
Publicado: (2019)

Molecular Modeling Study on Tunnel Behavior in Different Histone Deacetylase Isoforms
por: Thangapandian, Sundarapandian, et al.
Publicado: (2012)

Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
por: Mehndiratta, Samir, et al.
Publicado: (2020)

p53-Induced Growth Arrest Is Regulated by the Mitochondrial SirT3 Deacetylase
por: Li, SiDe, et al.
Publicado: (2010)

Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease
por: Ansari, Aneesa, et al.
Publicado: (2016)

An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality
por: Ferrer, Christina M., et al.
Publicado: (2018)

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma
por: Garcia-Peterson, Liz Mariely, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_cc91hpq7g6rgihlibos7r0n80c