Cargando…

Dual Role of CREB in The Regulation of VSMC Proliferation: Mode of Activation Determines Pro- or Anti-Mitogenic Function

Vascular smooth muscle cell (VSMC) proliferation has been implicated in the development of restenosis after angioplasty, vein graft intimal thickening and atherogenesis. We investigated the mechanisms underlying positive and negative regulation of VSMC proliferation by the transcription factor cycli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hudson, Claire, Kimura, Tomomi E., Duggirala, Aparna, Sala-Newby, Graciela B., Newby, Andrew C., Bond, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861041/ https://www.ncbi.nlm.nih.gov/pubmed/29559698 http://dx.doi.org/10.1038/s41598-018-23199-4

Ejemplares similares

The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP
por: Kimura, Tomomi E., et al.
Publicado: (2016)

cAMP-induced actin cytoskeleton remodelling inhibits MKL1-dependent expression of the chemotactic and pro-proliferative factor, CCN1
por: Duggirala, Aparna, et al.
Publicado: (2015)

Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells
por: Kimura, Tomomi E., et al.
Publicado: (2014)

Divergent Regulation of Actin Dynamics and Megakaryoblastic Leukemia-1 and -2 (Mkl1/2) by cAMP in Endothelial and Smooth Muscle Cells
por: Smith, Madeleine C., et al.
Publicado: (2017)

PKA and Epac synergistically inhibit smooth muscle cell proliferation
por: Hewer, Richard C., et al.
Publicado: (2011)

Classical Macrophage Activation Up-Regulates Several Matrix Metalloproteinases through Mitogen Activated Protein Kinases and Nuclear Factor-κB
por: Huang, Wei-Chun, et al.
Publicado: (2012)

Nuclear actin regulates cell proliferation and migration via inhibition of SRF and TEAD
por: McNeill, Madeleine C., et al.
Publicado: (2020)

S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo
por: Wu, Yih-Jer, et al.
Publicado: (2009)

Regulation of Epigenetic Modifiers, Including KDM6B, by Interferon-γ and Interleukin-4 in Human Macrophages
por: Yıldırım-Buharalıoğlu, Gökçe, et al.
Publicado: (2017)

miRNA-145 inhibits VSMC proliferation by targeting CD40
por: Guo, Xin, et al.
Publicado: (2016)

Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress
por: Arun, Mehmet Zuhuri, et al.
Publicado: (2016)

Overexpression of scavenger receptor LOX-1 in endothelial cells promotes atherogenesis in the ApoE(−/−) mouse model
por: White, Stephen J., et al.
Publicado: (2011)

Soluble N-cadherin: A novel inhibitor of VSMC proliferation and intimal thickening
por: Lyon, Cressida A., et al.
Publicado: (2016)

NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension
por: Sun, Hai-Jian, et al.
Publicado: (2017)

Diverse patterns of cyclooxygenase-independent metalloproteinase gene regulation in human monocytes
por: Reel, Buket, et al.
Publicado: (2011)

Pitavastatin Regulates Ang II Induced Proliferation and Migration via IGFBP-5 in VSMC
por: Ha, Yu Mi, et al.
Publicado: (2015)

Ending Restenosis: Inhibition of Vascular Smooth Muscle Cell Proliferation by cAMP
por: Smith, Sarah A., et al.
Publicado: (2019)

Luteolin Inhibits Angiotensin II-Stimulated VSMC Proliferation and Migration through Downregulation of Akt Phosphorylation
por: Xu, Tongda, et al.
Publicado: (2015)

Mesoglycan attenuates VSMC proliferation through activation of AMP-activated protein kinase and mTOR
por: Lee, Kyung Young, et al.
Publicado: (2016)

AKT Mediates Adiponectin-Dependent Regulation of VSMC Phenotype
por: Cullen, Abigail E., et al.
Publicado: (2023)

Lysyl oxidase (LOX) limits VSMC proliferation and neointimal thickening through its extracellular enzymatic activity
por: Varona, Saray, et al.
Publicado: (2018)

Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway
por: Wu, Xiaoyun, et al.
Publicado: (2022)

Gluten Exorphins Promote Cell Proliferation through the Activation of Mitogenic and Pro-Survival Pathways
por: Manai, Federico, et al.
Publicado: (2023)

Effects of Adenosine on Lymphangiogenesis
por: Lenoir, Bénédicte, et al.
Publicado: (2014)

PPARγ Inhibits VSMC Proliferation and Migration via Attenuating Oxidative Stress through Upregulating UCP2
por: Zhou, Yi, et al.
Publicado: (2016)

Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation
por: Wu, Wen, et al.
Publicado: (2019)

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment
por: Sonntag, Tim, et al.
Publicado: (2018)

Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells
por: Teasdale, Jack E., et al.
Publicado: (2017)

5′-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection
por: Zong, Tingyu, et al.
Publicado: (2021)

p38 MAPK priming boosts VSMC proliferation and arteriogenesis by promoting PGC1α-dependent mitochondrial dynamics
por: Sahún-Español, Álvaro, et al.
Publicado: (2022)

BGP-15 Inhibits Hyperglycemia-Aggravated VSMC Calcification Induced by High Phosphate
por: Nagy, Annamária, et al.
Publicado: (2021)

SENP2 Promotes VSMC Phenotypic Switching via Myocardin De-SUMOylation
por: Liang, Min, et al.
Publicado: (2022)

Targeting Wnt/β-Catenin Activated Cells with Dominant-Negative N-cadherin to Reduce Neointima Formation
por: Hulin-Curtis, Sarah, et al.
Publicado: (2017)

Patients with unstable angina and myocardial infarction expose remote VSMC phenotype switch and alteration in the proliferation of smooth muscular cell in the aortic wall
por: Woo, Chin Cheng, et al.
Publicado: (2015)

PI16 is a shear stress and inflammation-regulated inhibitor of MMP2
por: Hazell, Georgina G. J., et al.
Publicado: (2016)

EC4, a truncation of soluble N-cadherin, reduces vascular smooth muscle cell apoptosis and markers of atherosclerotic plaque instability
por: Lyon, Cressida A, et al.
Publicado: (2014)

Increased aerobic glycolysis is important for the motility of activated VSMC and inhibited by indirubin-3′-monoxime
por: Heiss, Elke H., et al.
Publicado: (2016)

Hsa_circ_0031608: A Potential Modulator of VSMC Phenotype in the Rupture of Intracranial Aneurysms
por: Wang, Chuanchuan, et al.
Publicado: (2022)

Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases
por: Li, Jingwen, et al.
Publicado: (2023)

Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury
por: YAN, GAOLIANG, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_246u24qiuaqh1v4bv0mqnk6dnc