In vitro effects of hydroxyapatite containing toothpastes on dentin permeability after multiple applications and ageing

This in vitro study evaluated the effect of toothpastes with different active ingredients on dentin permeability using an extended protocol including multiple applications and several thermal ageing cycles in the presence or absence of human saliva. The Null hypothesis was that dentin permeability o...

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Autores principales: Hiller, Karl-Anton, Buchalla, Wolfgang, Grillmeier, Isabel, Neubauer, Christina, Schmalz, Gottfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861090/
https://www.ncbi.nlm.nih.gov/pubmed/29559639
http://dx.doi.org/10.1038/s41598-018-22764-1
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author Hiller, Karl-Anton
Buchalla, Wolfgang
Grillmeier, Isabel
Neubauer, Christina
Schmalz, Gottfried
author_facet Hiller, Karl-Anton
Buchalla, Wolfgang
Grillmeier, Isabel
Neubauer, Christina
Schmalz, Gottfried
author_sort Hiller, Karl-Anton
collection PubMed
description This in vitro study evaluated the effect of toothpastes with different active ingredients on dentin permeability using an extended protocol including multiple applications and several thermal ageing cycles in the presence or absence of human saliva. The Null hypothesis was that dentin permeability of a hydroxyapatite containing toothpaste (BR), a potassium nitrate (SP) and an arginine and calcium carbonate (EH) containing toothpaste were similar. Dentin permeability was measured as hydraulic conductance using a commercially available capillary flow system (Flodec, Geneva) and results were expressed as % relative to matching controls. Without saliva, the ranking (best first) of dentin permeability was BR(61%) < SP(87%) < EH(118%), with saliva EH(63%) < SP(72%) < BR(88%). Saliva increased or decreased permeability dependent upon the test material. BR reduced dentin permeability significantly more in absence of saliva, with saliva EH was superior to BR. Repeated material application decreased and thermal ageing increased dentin permeability. The different tooth pastes reduced permeability differently, the best being BR without saliva, the least EH without saliva. The newly introduced test conditions (ageing, saliva, multiple applications) influenced single results significantly, and as they better simulate the in vivo situation they should be considered to be included in further in vitro permeability testing of desensitizing preparations.
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spelling pubmed-58610902018-03-26 In vitro effects of hydroxyapatite containing toothpastes on dentin permeability after multiple applications and ageing Hiller, Karl-Anton Buchalla, Wolfgang Grillmeier, Isabel Neubauer, Christina Schmalz, Gottfried Sci Rep Article This in vitro study evaluated the effect of toothpastes with different active ingredients on dentin permeability using an extended protocol including multiple applications and several thermal ageing cycles in the presence or absence of human saliva. The Null hypothesis was that dentin permeability of a hydroxyapatite containing toothpaste (BR), a potassium nitrate (SP) and an arginine and calcium carbonate (EH) containing toothpaste were similar. Dentin permeability was measured as hydraulic conductance using a commercially available capillary flow system (Flodec, Geneva) and results were expressed as % relative to matching controls. Without saliva, the ranking (best first) of dentin permeability was BR(61%) < SP(87%) < EH(118%), with saliva EH(63%) < SP(72%) < BR(88%). Saliva increased or decreased permeability dependent upon the test material. BR reduced dentin permeability significantly more in absence of saliva, with saliva EH was superior to BR. Repeated material application decreased and thermal ageing increased dentin permeability. The different tooth pastes reduced permeability differently, the best being BR without saliva, the least EH without saliva. The newly introduced test conditions (ageing, saliva, multiple applications) influenced single results significantly, and as they better simulate the in vivo situation they should be considered to be included in further in vitro permeability testing of desensitizing preparations. Nature Publishing Group UK 2018-03-20 /pmc/articles/PMC5861090/ /pubmed/29559639 http://dx.doi.org/10.1038/s41598-018-22764-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hiller, Karl-Anton
Buchalla, Wolfgang
Grillmeier, Isabel
Neubauer, Christina
Schmalz, Gottfried
In vitro effects of hydroxyapatite containing toothpastes on dentin permeability after multiple applications and ageing
title In vitro effects of hydroxyapatite containing toothpastes on dentin permeability after multiple applications and ageing
title_full In vitro effects of hydroxyapatite containing toothpastes on dentin permeability after multiple applications and ageing
title_fullStr In vitro effects of hydroxyapatite containing toothpastes on dentin permeability after multiple applications and ageing
title_full_unstemmed In vitro effects of hydroxyapatite containing toothpastes on dentin permeability after multiple applications and ageing
title_short In vitro effects of hydroxyapatite containing toothpastes on dentin permeability after multiple applications and ageing
title_sort in vitro effects of hydroxyapatite containing toothpastes on dentin permeability after multiple applications and ageing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861090/
https://www.ncbi.nlm.nih.gov/pubmed/29559639
http://dx.doi.org/10.1038/s41598-018-22764-1
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