Human cytochrome P450 2B6 genetic variability in Botswana: a case of haplotype diversity and convergent phenotypes

Identification of inter-individual variability for drug metabolism through cytochrome P450 2B6 (CYP2B6) enzyme is important for understanding the differences in clinical responses to malaria and HIV. This study evaluates the distribution of CYP2B6 alleles, haplotypes and inferred metabolic phenotype...

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Detalles Bibliográficos
Autores principales: Tawe, Leabaneng, Motshoge, Thato, Ramatlho, Pleasure, Mutukwa, Naledi, Muthoga, Charles Waithaka, Dongho, Ghyslaine Bruna Djeunang, Martinelli, Axel, Peloewetse, Elias, Russo, Gianluca, Quaye, Isaac Kweku, Paganotti, Giacomo Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861095/
https://www.ncbi.nlm.nih.gov/pubmed/29559695
http://dx.doi.org/10.1038/s41598-018-23350-1

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