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Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis

The conserved decapping enzyme Dcp2 recognizes and removes the 5′ eukaryotic cap from mRNA transcripts in a critical step of many cellular RNA decay pathways. Dcp2 is a dynamic enzyme that functions in concert with the essential activator Dcp1 and a diverse set of coactivators to selectively and eff...

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Detalles Bibliográficos
Autores principales:	Mugridge, Jeffrey S., Tibble, Ryan W., Ziemniak, Marcin, Jemielity, Jacek, Gross, John D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861098/ https://www.ncbi.nlm.nih.gov/pubmed/29559651 http://dx.doi.org/10.1038/s41467-018-03536-x

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