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Pacemaker Implantation Associated Myocardial Micro-Damage: A Randomised Comparison between Active and Passive Fixation Leads

Fixation of the pacemaker leads during pacemaker implantation leads to an increase of cardiac Troponin T (cTnT) that can be interpreted as a sign of minimal myocardial damage. This trial evaluates whether the mechanism type of lead fixation influences the magnitude of cTnT release. Patients having a...

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Autores principales: Blažek, Patrick, Ferri-Certić, Jerko, Vražić, Hrvoje, Lennerz, Carsten, Grebmer, Christian, Kaitani, Kazuaki, Karch, Martin, Starčević, Boris, Semmler, Verena, Kolb, Christof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861101/
https://www.ncbi.nlm.nih.gov/pubmed/29559697
http://dx.doi.org/10.1038/s41598-018-23209-5
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author Blažek, Patrick
Ferri-Certić, Jerko
Vražić, Hrvoje
Lennerz, Carsten
Grebmer, Christian
Kaitani, Kazuaki
Karch, Martin
Starčević, Boris
Semmler, Verena
Kolb, Christof
author_facet Blažek, Patrick
Ferri-Certić, Jerko
Vražić, Hrvoje
Lennerz, Carsten
Grebmer, Christian
Kaitani, Kazuaki
Karch, Martin
Starčević, Boris
Semmler, Verena
Kolb, Christof
author_sort Blažek, Patrick
collection PubMed
description Fixation of the pacemaker leads during pacemaker implantation leads to an increase of cardiac Troponin T (cTnT) that can be interpreted as a sign of minimal myocardial damage. This trial evaluates whether the mechanism type of lead fixation influences the magnitude of cTnT release. Patients having a de-novo cardiac pacemaker implantation or a lead revision were centrally randomized to receive either a ventricular lead with an active (screw) or passive (tine) fixation mechanism. High-sensitive Troponin T (hsTnT) was determined on the day of the procedure beforehand and on the following day. 326 Patients (median age (IQR) 75.0 (69.0–80.0) years, 64% male) from six international centers were randomized to receive ventricular leads with an active (n = 166) or passive (n = 160) fixation mechanism. Median (IQR) hsTnT levels increased by 0.009 (0.004–0.021) ng/ml in the group receiving screw-in ventricular leads and by 0.008 (0.003–0.030) ng/ml in the group receiving tined ventricular leads (n.s.). In conclusion pacemaker implantations are followed by a release of hsTnT. The choice between active or passive fixation ventricular leads does not have a significant influence on the extent of myocardial injury and the magnitude of hsTnT release.
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spelling pubmed-58611012018-03-26 Pacemaker Implantation Associated Myocardial Micro-Damage: A Randomised Comparison between Active and Passive Fixation Leads Blažek, Patrick Ferri-Certić, Jerko Vražić, Hrvoje Lennerz, Carsten Grebmer, Christian Kaitani, Kazuaki Karch, Martin Starčević, Boris Semmler, Verena Kolb, Christof Sci Rep Article Fixation of the pacemaker leads during pacemaker implantation leads to an increase of cardiac Troponin T (cTnT) that can be interpreted as a sign of minimal myocardial damage. This trial evaluates whether the mechanism type of lead fixation influences the magnitude of cTnT release. Patients having a de-novo cardiac pacemaker implantation or a lead revision were centrally randomized to receive either a ventricular lead with an active (screw) or passive (tine) fixation mechanism. High-sensitive Troponin T (hsTnT) was determined on the day of the procedure beforehand and on the following day. 326 Patients (median age (IQR) 75.0 (69.0–80.0) years, 64% male) from six international centers were randomized to receive ventricular leads with an active (n = 166) or passive (n = 160) fixation mechanism. Median (IQR) hsTnT levels increased by 0.009 (0.004–0.021) ng/ml in the group receiving screw-in ventricular leads and by 0.008 (0.003–0.030) ng/ml in the group receiving tined ventricular leads (n.s.). In conclusion pacemaker implantations are followed by a release of hsTnT. The choice between active or passive fixation ventricular leads does not have a significant influence on the extent of myocardial injury and the magnitude of hsTnT release. Nature Publishing Group UK 2018-03-20 /pmc/articles/PMC5861101/ /pubmed/29559697 http://dx.doi.org/10.1038/s41598-018-23209-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Blažek, Patrick
Ferri-Certić, Jerko
Vražić, Hrvoje
Lennerz, Carsten
Grebmer, Christian
Kaitani, Kazuaki
Karch, Martin
Starčević, Boris
Semmler, Verena
Kolb, Christof
Pacemaker Implantation Associated Myocardial Micro-Damage: A Randomised Comparison between Active and Passive Fixation Leads
title Pacemaker Implantation Associated Myocardial Micro-Damage: A Randomised Comparison between Active and Passive Fixation Leads
title_full Pacemaker Implantation Associated Myocardial Micro-Damage: A Randomised Comparison between Active and Passive Fixation Leads
title_fullStr Pacemaker Implantation Associated Myocardial Micro-Damage: A Randomised Comparison between Active and Passive Fixation Leads
title_full_unstemmed Pacemaker Implantation Associated Myocardial Micro-Damage: A Randomised Comparison between Active and Passive Fixation Leads
title_short Pacemaker Implantation Associated Myocardial Micro-Damage: A Randomised Comparison between Active and Passive Fixation Leads
title_sort pacemaker implantation associated myocardial micro-damage: a randomised comparison between active and passive fixation leads
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861101/
https://www.ncbi.nlm.nih.gov/pubmed/29559697
http://dx.doi.org/10.1038/s41598-018-23209-5
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