Plasmodium falciparum Liver Stage Infection and Transition to Stable Blood Stage Infection in Liver-Humanized and Blood-Humanized FRGN KO Mice Enables Testing of Blood Stage Inhibitory Antibodies (Reticulocyte-Binding Protein Homolog 5) In Vivo

The invention of liver-humanized mouse models has made it possible to directly study the preerythrocytic stages of Plasmodium falciparum. In contrast, the current models to directly study blood stage infection in vivo are extremely limited. Humanization of the mouse blood stream is achievable by fre...

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Detalles Bibliográficos
Autores principales: Foquet, Lander, Schafer, Carola, Minkah, Nana K., Alanine, Daniel G. W., Flannery, Erika L., Steel, Ryan W. J., Sack, Brandon K., Camargo, Nelly, Fishbaugher, Matthew, Betz, Will, Nguyen, Thao, Billman, Zachary P., Wilson, Elizabeth M., Bial, John, Murphy, Sean C., Draper, Simon J., Mikolajczak, Sebastian A., Kappe, Stefan H. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861195/
https://www.ncbi.nlm.nih.gov/pubmed/29593746
http://dx.doi.org/10.3389/fimmu.2018.00524

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