CRISPR/Cas9-mediated modulation of splicing efficiency reveals short splicing isoform of Xist RNA is sufficient to induce X-chromosome inactivation

Alternative splicing of mRNA precursors results in multiple protein variants from a single gene and is critical for diverse cellular processes and development. Xist encodes a long noncoding RNA which is a central player to induce X-chromosome inactivation in female mammals and has two major splicing...

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Detalles Bibliográficos
Autores principales: Yue, Minghui, Ogawa, Yuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861412/
https://www.ncbi.nlm.nih.gov/pubmed/29237010
http://dx.doi.org/10.1093/nar/gkx1227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861412/
https://www.ncbi.nlm.nih.gov/pubmed/29237010
http://dx.doi.org/10.1093/nar/gkx1227

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