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Childhood food allergies: An evolutionary mismatch hypothesis
For hominins living in the Paleolithic era, early food antigen exposures—in utero and throughout infancy—closely matched later exposures, and therefore immune system tolerance mechanisms evolved under the expectation of this condition being met. This predicts that the degree of mismatch between earl...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Oxford University Press
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861434/ https://www.ncbi.nlm.nih.gov/pubmed/29593870 http://dx.doi.org/10.1093/emph/eox014 |
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author | Turke, Paul W |
author_facet | Turke, Paul W |
author_sort | Turke, Paul W |
collection | PubMed |
description | For hominins living in the Paleolithic era, early food antigen exposures—in utero and throughout infancy—closely matched later exposures, and therefore immune system tolerance mechanisms evolved under the expectation of this condition being met. This predicts that the degree of mismatch between early and downstream food antigen exposures is a key variable underlying the development of childhood food allergies. Three historical periods are identified in which the degree of mismatch climbs from near zero to substantial, as we transition from one period to another. The first encompasses our long history as foragers; the second begins with the advent of farming and the third spans only the most recent two or three decades, and manifests from social changes driven largely by an explosion in access to information. Testable predictions are generated and evaluated in light of available evidence, and an approach for primary prevention of childhood food allergies is proposed. |
format | Online Article Text |
id | pubmed-5861434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58614342018-03-28 Childhood food allergies: An evolutionary mismatch hypothesis Turke, Paul W Evol Med Public Health Invited Commentary For hominins living in the Paleolithic era, early food antigen exposures—in utero and throughout infancy—closely matched later exposures, and therefore immune system tolerance mechanisms evolved under the expectation of this condition being met. This predicts that the degree of mismatch between early and downstream food antigen exposures is a key variable underlying the development of childhood food allergies. Three historical periods are identified in which the degree of mismatch climbs from near zero to substantial, as we transition from one period to another. The first encompasses our long history as foragers; the second begins with the advent of farming and the third spans only the most recent two or three decades, and manifests from social changes driven largely by an explosion in access to information. Testable predictions are generated and evaluated in light of available evidence, and an approach for primary prevention of childhood food allergies is proposed. Oxford University Press 2017-10-04 /pmc/articles/PMC5861434/ /pubmed/29593870 http://dx.doi.org/10.1093/emph/eox014 Text en © The Author(s) 2017. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Commentary Turke, Paul W Childhood food allergies: An evolutionary mismatch hypothesis |
title | Childhood food allergies: An evolutionary mismatch hypothesis |
title_full | Childhood food allergies: An evolutionary mismatch hypothesis |
title_fullStr | Childhood food allergies: An evolutionary mismatch hypothesis |
title_full_unstemmed | Childhood food allergies: An evolutionary mismatch hypothesis |
title_short | Childhood food allergies: An evolutionary mismatch hypothesis |
title_sort | childhood food allergies: an evolutionary mismatch hypothesis |
topic | Invited Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861434/ https://www.ncbi.nlm.nih.gov/pubmed/29593870 http://dx.doi.org/10.1093/emph/eox014 |
work_keys_str_mv | AT turkepaulw childhoodfoodallergiesanevolutionarymismatchhypothesis |