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Intragenomic Conflict and Immune Tolerance: Do Selfish X-Linked Alleles Drive Skewed X Chromosome Inactivation?
In mammalian females, diploid somatic cells contain two X chromosomes, one of which is transcriptionally silenced, in a process termed X chromosome inactivation (XCI). Whereas XCI is largely random in placental females, many women exhibit skewed XCI (SXCI), in which the vast majority cells have the...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Oxford University Press
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861445/ https://www.ncbi.nlm.nih.gov/pubmed/29092048 http://dx.doi.org/10.1093/gbe/evx221 |