Protein-mediated looping of DNA under tension requires supercoiling

Protein-mediated DNA looping is ubiquitous in chromatin organization and gene regulation, but to what extent supercoiling or nucleoid associated proteins promote looping is poorly understood. Using the lac repressor (LacI), a paradigmatic loop-mediating protein, we measured LacI-induced looping as a...

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Detalles Bibliográficos
Autores principales: Yan, Yan, Leng, Fenfei, Finzi, Laura, Dunlap, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861448/
https://www.ncbi.nlm.nih.gov/pubmed/29365152
http://dx.doi.org/10.1093/nar/gky021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861448/
https://www.ncbi.nlm.nih.gov/pubmed/29365152
http://dx.doi.org/10.1093/nar/gky021

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