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Protein-mediated looping of DNA under tension requires supercoiling
Protein-mediated DNA looping is ubiquitous in chromatin organization and gene regulation, but to what extent supercoiling or nucleoid associated proteins promote looping is poorly understood. Using the lac repressor (LacI), a paradigmatic loop-mediating protein, we measured LacI-induced looping as a...
Autores principales: | Yan, Yan, Leng, Fenfei, Finzi, Laura, Dunlap, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861448/ https://www.ncbi.nlm.nih.gov/pubmed/29365152 http://dx.doi.org/10.1093/nar/gky021 |
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