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Zika virus: Current concerns in India
With confirmation of Zika virus (ZIKV) presence in India, screening of a large number of febrile illness samples yielded only four positive cases. In this review, we address the current concern with context to India. The possible reasons for low level of Zika prevalence in India have been discussed,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861468/ https://www.ncbi.nlm.nih.gov/pubmed/29512599 http://dx.doi.org/10.4103/ijmr.IJMR_1160_17 |
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author | Bhardwaj, Sumit Gokhale, Mangesh D. Mourya, Devendra T. |
author_facet | Bhardwaj, Sumit Gokhale, Mangesh D. Mourya, Devendra T. |
author_sort | Bhardwaj, Sumit |
collection | PubMed |
description | With confirmation of Zika virus (ZIKV) presence in India, screening of a large number of febrile illness samples yielded only four positive cases. In this review, we address the current concern with context to India. The possible reasons for low level of Zika prevalence in India have been discussed, by extracting some probable explanations from previous experience of chikungunya virus-vector model/studies. In the current context, it is hypothesized that Indian mosquito strains have lower susceptibility gradient/threshold for ZIKV. The very low positivity in the humans also indicates low levels of mosquito-human-mosquito transmission cycle. There is also a need to look for the existence of any such animal cycle/sylvatic involvement in India. The recently detected four cases in India show local transmission of ZIKV suggesting that ZIKV might have been present in India since long time. The earlier vector-virus relationship studies with chikungunya suggested that in due course of time, ZIKV might become a major public health concern in the future. |
format | Online Article Text |
id | pubmed-5861468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-58614682018-04-06 Zika virus: Current concerns in India Bhardwaj, Sumit Gokhale, Mangesh D. Mourya, Devendra T. Indian J Med Res Review Article With confirmation of Zika virus (ZIKV) presence in India, screening of a large number of febrile illness samples yielded only four positive cases. In this review, we address the current concern with context to India. The possible reasons for low level of Zika prevalence in India have been discussed, by extracting some probable explanations from previous experience of chikungunya virus-vector model/studies. In the current context, it is hypothesized that Indian mosquito strains have lower susceptibility gradient/threshold for ZIKV. The very low positivity in the humans also indicates low levels of mosquito-human-mosquito transmission cycle. There is also a need to look for the existence of any such animal cycle/sylvatic involvement in India. The recently detected four cases in India show local transmission of ZIKV suggesting that ZIKV might have been present in India since long time. The earlier vector-virus relationship studies with chikungunya suggested that in due course of time, ZIKV might become a major public health concern in the future. Medknow Publications & Media Pvt Ltd 2017-11 /pmc/articles/PMC5861468/ /pubmed/29512599 http://dx.doi.org/10.4103/ijmr.IJMR_1160_17 Text en Copyright: © 2018 Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Bhardwaj, Sumit Gokhale, Mangesh D. Mourya, Devendra T. Zika virus: Current concerns in India |
title | Zika virus: Current concerns in India |
title_full | Zika virus: Current concerns in India |
title_fullStr | Zika virus: Current concerns in India |
title_full_unstemmed | Zika virus: Current concerns in India |
title_short | Zika virus: Current concerns in India |
title_sort | zika virus: current concerns in india |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861468/ https://www.ncbi.nlm.nih.gov/pubmed/29512599 http://dx.doi.org/10.4103/ijmr.IJMR_1160_17 |
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