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Zika virus: Current concerns in India

With confirmation of Zika virus (ZIKV) presence in India, screening of a large number of febrile illness samples yielded only four positive cases. In this review, we address the current concern with context to India. The possible reasons for low level of Zika prevalence in India have been discussed,...

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Autores principales: Bhardwaj, Sumit, Gokhale, Mangesh D., Mourya, Devendra T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861468/
https://www.ncbi.nlm.nih.gov/pubmed/29512599
http://dx.doi.org/10.4103/ijmr.IJMR_1160_17
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author Bhardwaj, Sumit
Gokhale, Mangesh D.
Mourya, Devendra T.
author_facet Bhardwaj, Sumit
Gokhale, Mangesh D.
Mourya, Devendra T.
author_sort Bhardwaj, Sumit
collection PubMed
description With confirmation of Zika virus (ZIKV) presence in India, screening of a large number of febrile illness samples yielded only four positive cases. In this review, we address the current concern with context to India. The possible reasons for low level of Zika prevalence in India have been discussed, by extracting some probable explanations from previous experience of chikungunya virus-vector model/studies. In the current context, it is hypothesized that Indian mosquito strains have lower susceptibility gradient/threshold for ZIKV. The very low positivity in the humans also indicates low levels of mosquito-human-mosquito transmission cycle. There is also a need to look for the existence of any such animal cycle/sylvatic involvement in India. The recently detected four cases in India show local transmission of ZIKV suggesting that ZIKV might have been present in India since long time. The earlier vector-virus relationship studies with chikungunya suggested that in due course of time, ZIKV might become a major public health concern in the future.
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spelling pubmed-58614682018-04-06 Zika virus: Current concerns in India Bhardwaj, Sumit Gokhale, Mangesh D. Mourya, Devendra T. Indian J Med Res Review Article With confirmation of Zika virus (ZIKV) presence in India, screening of a large number of febrile illness samples yielded only four positive cases. In this review, we address the current concern with context to India. The possible reasons for low level of Zika prevalence in India have been discussed, by extracting some probable explanations from previous experience of chikungunya virus-vector model/studies. In the current context, it is hypothesized that Indian mosquito strains have lower susceptibility gradient/threshold for ZIKV. The very low positivity in the humans also indicates low levels of mosquito-human-mosquito transmission cycle. There is also a need to look for the existence of any such animal cycle/sylvatic involvement in India. The recently detected four cases in India show local transmission of ZIKV suggesting that ZIKV might have been present in India since long time. The earlier vector-virus relationship studies with chikungunya suggested that in due course of time, ZIKV might become a major public health concern in the future. Medknow Publications & Media Pvt Ltd 2017-11 /pmc/articles/PMC5861468/ /pubmed/29512599 http://dx.doi.org/10.4103/ijmr.IJMR_1160_17 Text en Copyright: © 2018 Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Bhardwaj, Sumit
Gokhale, Mangesh D.
Mourya, Devendra T.
Zika virus: Current concerns in India
title Zika virus: Current concerns in India
title_full Zika virus: Current concerns in India
title_fullStr Zika virus: Current concerns in India
title_full_unstemmed Zika virus: Current concerns in India
title_short Zika virus: Current concerns in India
title_sort zika virus: current concerns in india
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861468/
https://www.ncbi.nlm.nih.gov/pubmed/29512599
http://dx.doi.org/10.4103/ijmr.IJMR_1160_17
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