Recent advances in understanding West Nile virus host immunity and viral pathogenesis

West Nile virus (WNV), a mosquito-borne flavivirus, has been a significant public health concern in the United States for nearly two decades. The virus has been linked to acute viral encephalitis, neurological sequelae, and chronic kidney diseases. Neither antiviral drugs nor vaccines are currently...

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Autores principales: Luo, Huanle, Wang, Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861506/
https://www.ncbi.nlm.nih.gov/pubmed/29623197
http://dx.doi.org/10.12688/f1000research.13362.1
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author Luo, Huanle
Wang, Tian
author_facet Luo, Huanle
Wang, Tian
author_sort Luo, Huanle
collection PubMed
description West Nile virus (WNV), a mosquito-borne flavivirus, has been a significant public health concern in the United States for nearly two decades. The virus has been linked to acute viral encephalitis, neurological sequelae, and chronic kidney diseases. Neither antiviral drugs nor vaccines are currently available for humans. In vitro cell culture and experimental animal models have been used to study WNV infection in humans. In this review, we will focus on recent findings and provide new insights into WNV host immunity and viral pathogenesis.
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spelling pubmed-58615062018-04-04 Recent advances in understanding West Nile virus host immunity and viral pathogenesis Luo, Huanle Wang, Tian F1000Res Review West Nile virus (WNV), a mosquito-borne flavivirus, has been a significant public health concern in the United States for nearly two decades. The virus has been linked to acute viral encephalitis, neurological sequelae, and chronic kidney diseases. Neither antiviral drugs nor vaccines are currently available for humans. In vitro cell culture and experimental animal models have been used to study WNV infection in humans. In this review, we will focus on recent findings and provide new insights into WNV host immunity and viral pathogenesis. F1000 Research Limited 2018-03-19 /pmc/articles/PMC5861506/ /pubmed/29623197 http://dx.doi.org/10.12688/f1000research.13362.1 Text en Copyright: © 2018 Luo H and Wang T http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Luo, Huanle
Wang, Tian
Recent advances in understanding West Nile virus host immunity and viral pathogenesis
title Recent advances in understanding West Nile virus host immunity and viral pathogenesis
title_full Recent advances in understanding West Nile virus host immunity and viral pathogenesis
title_fullStr Recent advances in understanding West Nile virus host immunity and viral pathogenesis
title_full_unstemmed Recent advances in understanding West Nile virus host immunity and viral pathogenesis
title_short Recent advances in understanding West Nile virus host immunity and viral pathogenesis
title_sort recent advances in understanding west nile virus host immunity and viral pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861506/
https://www.ncbi.nlm.nih.gov/pubmed/29623197
http://dx.doi.org/10.12688/f1000research.13362.1
work_keys_str_mv AT luohuanle recentadvancesinunderstandingwestnilevirushostimmunityandviralpathogenesis
AT wangtian recentadvancesinunderstandingwestnilevirushostimmunityandviralpathogenesis

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