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Mitochondrial dysfunction in an animal model of diabetic neuropathy is associated with a reduction of neurosteroid synthesis.
Background : Recent work in a model of diabetic neuropathy revealed that layer 2/3 cortical pyramidal neurones of the pain pathway exhibited reduced endogenous neurosteroid modulation of the GABA (A)R and exogenously applied neurosteroids had an exaggerated impact. It is postulated that this is rela...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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F1000 Research Limited
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861509/ https://www.ncbi.nlm.nih.gov/pubmed/29623189 http://dx.doi.org/10.12688/f1000research.11056.2 |