The physiological functions of central nervous system pericytes and a potential role in pain

Central nervous system (CNS) pericytes regulate critical functions of the neurovascular unit in health and disease. CNS pericytes are an attractive pharmacological target for their position within the neurovasculature and for their role in neuroinflammation. Whether the function of CNS pericytes als...

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Detalles Bibliográficos
Autores principales: Beazley-Long, Nicholas, Durrant, Alexandra M, Swift, Matthew N, Donaldson, Lucy F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861511/
https://www.ncbi.nlm.nih.gov/pubmed/29623199
http://dx.doi.org/10.12688/f1000research.13548.1
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author Beazley-Long, Nicholas
Durrant, Alexandra M
Swift, Matthew N
Donaldson, Lucy F
author_facet Beazley-Long, Nicholas
Durrant, Alexandra M
Swift, Matthew N
Donaldson, Lucy F
author_sort Beazley-Long, Nicholas
collection PubMed
description Central nervous system (CNS) pericytes regulate critical functions of the neurovascular unit in health and disease. CNS pericytes are an attractive pharmacological target for their position within the neurovasculature and for their role in neuroinflammation. Whether the function of CNS pericytes also affects pain states and nociceptive mechanisms is currently not understood. Could it be that pericytes hold the key to pain associated with CNS blood vessel dysfunction? This article reviews recent findings on the important physiological functions of CNS pericytes and highlights how these neurovascular functions could be linked to pain states.
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spelling pubmed-58615112018-04-04 The physiological functions of central nervous system pericytes and a potential role in pain Beazley-Long, Nicholas Durrant, Alexandra M Swift, Matthew N Donaldson, Lucy F F1000Res Review Central nervous system (CNS) pericytes regulate critical functions of the neurovascular unit in health and disease. CNS pericytes are an attractive pharmacological target for their position within the neurovasculature and for their role in neuroinflammation. Whether the function of CNS pericytes also affects pain states and nociceptive mechanisms is currently not understood. Could it be that pericytes hold the key to pain associated with CNS blood vessel dysfunction? This article reviews recent findings on the important physiological functions of CNS pericytes and highlights how these neurovascular functions could be linked to pain states. F1000 Research Limited 2018-03-20 /pmc/articles/PMC5861511/ /pubmed/29623199 http://dx.doi.org/10.12688/f1000research.13548.1 Text en Copyright: © 2018 Beazley-Long N et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Beazley-Long, Nicholas
Durrant, Alexandra M
Swift, Matthew N
Donaldson, Lucy F
The physiological functions of central nervous system pericytes and a potential role in pain
title The physiological functions of central nervous system pericytes and a potential role in pain
title_full The physiological functions of central nervous system pericytes and a potential role in pain
title_fullStr The physiological functions of central nervous system pericytes and a potential role in pain
title_full_unstemmed The physiological functions of central nervous system pericytes and a potential role in pain
title_short The physiological functions of central nervous system pericytes and a potential role in pain
title_sort physiological functions of central nervous system pericytes and a potential role in pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861511/
https://www.ncbi.nlm.nih.gov/pubmed/29623199
http://dx.doi.org/10.12688/f1000research.13548.1
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