Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury

BACKGROUND: Traumatic spinal cord injury (SCI) results in upregulation of chondroitin sulfate proteoglycans (CSPGs) by reactive glia that impedes repair and regeneration in the spinal cord. Degradation of CSPGs is known to be beneficial in promoting endogenous repair mechanisms including axonal spro...

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Detalles Bibliográficos
Autores principales: Dyck, Scott, Kataria, Hardeep, Alizadeh, Arsalan, Santhosh, Kallivalappil T., Lang, Bradley, Silver, Jerry, Karimi-Abdolrezaee, Soheila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861616/
https://www.ncbi.nlm.nih.gov/pubmed/29558941
http://dx.doi.org/10.1186/s12974-018-1128-2

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