MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner

BACKGROUND: Fibroblasts are crucial mediators of tumor-stroma cross-talk through synthesis and remodeling of the extracellular matrix and production of multiple soluble factors. Nonetheless, little is still known about specific determinants of fibroblast pro-tumorigenic activity in lung cancer. Here...

Descripción completa

Detalles Bibliográficos
Autores principales: Andriani, Francesca, Majorini, Maria Teresa, Mano, Miguel, Landoni, Elena, Miceli, Rosalba, Facchinetti, Federica, Mensah, Mavis, Fontanella, Enrico, Dugo, Matteo, Giacca, Mauro, Pastorino, Ugo, Sozzi, Gabriella, Delia, Domenico, Roz, Luca, Lecis, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861674/
https://www.ncbi.nlm.nih.gov/pubmed/29558956
http://dx.doi.org/10.1186/s13045-018-0594-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861674/
https://www.ncbi.nlm.nih.gov/pubmed/29558956
http://dx.doi.org/10.1186/s13045-018-0594-4

Ejemplares similares