Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy

BACKGROUND: The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammation proce...

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Detalles Bibliográficos
Autores principales: Boursereau, Raphaël, Abou-Samra, Michel, Lecompte, Sophie, Noel, Laurence, Brichard, Sonia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861675/
https://www.ncbi.nlm.nih.gov/pubmed/29558930
http://dx.doi.org/10.1186/s12915-018-0501-z

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