Monoclonal antibody exposure in rat and cynomolgus monkey cerebrospinal fluid following systemic administration

BACKGROUND: Many studies have focused on the challenges of small molecule uptake across the blood–brain barrier, whereas few in-depth studies have assessed the challenges with the uptake of antibodies into the central nervous system (CNS). In drug development, cerebrospinal fluid (CSF) sampling is r...

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Detalles Bibliográficos
Autores principales: Wang, Qin, Delva, Luisette, Weinreb, Paul H., Pepinsky, Robert B., Graham, Danielle, Veizaj, Elvana, Cheung, Anne E., Chen, Weiping, Nestorov, Ivan, Rohde, Ellen, Caputo, Robin, Kuesters, Geoffrey M., Bohnert, Tonika, Gan, Liang-Shang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861715/
https://www.ncbi.nlm.nih.gov/pubmed/29558954
http://dx.doi.org/10.1186/s12987-018-0093-6

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