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Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson’s Disease
BACKGROUND: Dementia is significant in Parkinson’s disease (PD) with personal and socioeconomic impact. Early identification of risk is of upmost importance to optimize management. Gait precedes and predicts cognitive decline and dementia in older adults. We aimed to evaluate gait characteristics as...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861960/ https://www.ncbi.nlm.nih.gov/pubmed/28472409 http://dx.doi.org/10.1093/gerona/glx071 |
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author | Morris, Rosie Lord, Sue Lawson, Rachael A Coleman, Shirley Galna, Brook Duncan, Gordon W Khoo, Tien K Yarnall, Alison J Burn, David J Rochester, Lynn |
author_facet | Morris, Rosie Lord, Sue Lawson, Rachael A Coleman, Shirley Galna, Brook Duncan, Gordon W Khoo, Tien K Yarnall, Alison J Burn, David J Rochester, Lynn |
author_sort | Morris, Rosie |
collection | PubMed |
description | BACKGROUND: Dementia is significant in Parkinson’s disease (PD) with personal and socioeconomic impact. Early identification of risk is of upmost importance to optimize management. Gait precedes and predicts cognitive decline and dementia in older adults. We aimed to evaluate gait characteristics as predictors of cognitive decline in newly diagnosed PD. METHODS: One hundred and nineteen participants recruited at diagnosis were assessed at baseline, 18 and 36 months. Baseline gait was characterized by variables that mapped to five domains: pace, rhythm, variability, asymmetry, and postural control. Cognitive assessment included attention, fluctuating attention, executive function, visual memory, and visuospatial function. Mixed-effects models tested independent gait predictors of cognitive decline. RESULTS: Gait characteristics of pace, variability, and postural control predicted decline in fluctuating attention and visual memory, whereas baseline neuropsychological assessment performance did not predict decline. CONCLUSIONS: This provides novel evidence for gait as a clinical biomarker for PD cognitive decline in early disease. |
format | Online Article Text |
id | pubmed-5861960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58619602018-03-28 Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson’s Disease Morris, Rosie Lord, Sue Lawson, Rachael A Coleman, Shirley Galna, Brook Duncan, Gordon W Khoo, Tien K Yarnall, Alison J Burn, David J Rochester, Lynn J Gerontol A Biol Sci Med Sci Research Article BACKGROUND: Dementia is significant in Parkinson’s disease (PD) with personal and socioeconomic impact. Early identification of risk is of upmost importance to optimize management. Gait precedes and predicts cognitive decline and dementia in older adults. We aimed to evaluate gait characteristics as predictors of cognitive decline in newly diagnosed PD. METHODS: One hundred and nineteen participants recruited at diagnosis were assessed at baseline, 18 and 36 months. Baseline gait was characterized by variables that mapped to five domains: pace, rhythm, variability, asymmetry, and postural control. Cognitive assessment included attention, fluctuating attention, executive function, visual memory, and visuospatial function. Mixed-effects models tested independent gait predictors of cognitive decline. RESULTS: Gait characteristics of pace, variability, and postural control predicted decline in fluctuating attention and visual memory, whereas baseline neuropsychological assessment performance did not predict decline. CONCLUSIONS: This provides novel evidence for gait as a clinical biomarker for PD cognitive decline in early disease. Oxford University Press 2017-11 2017-05-03 /pmc/articles/PMC5861960/ /pubmed/28472409 http://dx.doi.org/10.1093/gerona/glx071 Text en © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Morris, Rosie Lord, Sue Lawson, Rachael A Coleman, Shirley Galna, Brook Duncan, Gordon W Khoo, Tien K Yarnall, Alison J Burn, David J Rochester, Lynn Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson’s Disease |
title | Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson’s Disease |
title_full | Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson’s Disease |
title_fullStr | Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson’s Disease |
title_full_unstemmed | Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson’s Disease |
title_short | Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson’s Disease |
title_sort | gait rather than cognition predicts decline in specific cognitive domains in early parkinson’s disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861960/ https://www.ncbi.nlm.nih.gov/pubmed/28472409 http://dx.doi.org/10.1093/gerona/glx071 |
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