Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus aureus Colonization of Venous Catheters

Vascular catheters are a major cause of nosocomial bloodstream infections. ChloraLock (ATTWILL Medical Solutions, Inc, West Jordan, UT, and ICU Medical, Inc, San Clemente, CA) is a novel antimicrobial device containing chlorhexidine digluconate (CHG) that is fitted onto a syringe and infuses CHG int...

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Detalles Bibliográficos
Autores principales: Kowalewska, Paulina M., Petrik, Shawn M., Di Fiore, Attilio E., Fox-Robichaud, Alison E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health, Inc. 2018
Materias:
Features
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862007/
https://www.ncbi.nlm.nih.gov/pubmed/29489705
http://dx.doi.org/10.1097/NAN.0000000000000267
Descripción
Sumario:Vascular catheters are a major cause of nosocomial bloodstream infections. ChloraLock (ATTWILL Medical Solutions, Inc, West Jordan, UT, and ICU Medical, Inc, San Clemente, CA) is a novel antimicrobial device containing chlorhexidine digluconate (CHG) that is fitted onto a syringe and infuses CHG into the catheter lumen during locking. The objective of this study was to evaluate the antimicrobial efficacy of ChloraLock with in vitro tests and its ability to reduce Staphylococcus aureus contamination of catheters in the external jugular veins of Yorkshire swine. ChloraLock significantly reduced the bacterial load in the in vitro tests by up to 6 log(10) colony-forming units (CFU) and by 3 to 4 log(10) CFU/lumen in vivo in a swine model with 0.9% NaCl catheter locks.

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