Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus aureus Colonization of Venous Catheters

Vascular catheters are a major cause of nosocomial bloodstream infections. ChloraLock (ATTWILL Medical Solutions, Inc, West Jordan, UT, and ICU Medical, Inc, San Clemente, CA) is a novel antimicrobial device containing chlorhexidine digluconate (CHG) that is fitted onto a syringe and infuses CHG int...

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Autores principales: Kowalewska, Paulina M., Petrik, Shawn M., Di Fiore, Attilio E., Fox-Robichaud, Alison E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health, Inc. 2018
Materias:
Features
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862007/
https://www.ncbi.nlm.nih.gov/pubmed/29489705
http://dx.doi.org/10.1097/NAN.0000000000000267
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author Kowalewska, Paulina M.
Petrik, Shawn M.
Di Fiore, Attilio E.
Fox-Robichaud, Alison E.
author_facet Kowalewska, Paulina M.
Petrik, Shawn M.
Di Fiore, Attilio E.
Fox-Robichaud, Alison E.
author_sort Kowalewska, Paulina M.
collection PubMed
description Vascular catheters are a major cause of nosocomial bloodstream infections. ChloraLock (ATTWILL Medical Solutions, Inc, West Jordan, UT, and ICU Medical, Inc, San Clemente, CA) is a novel antimicrobial device containing chlorhexidine digluconate (CHG) that is fitted onto a syringe and infuses CHG into the catheter lumen during locking. The objective of this study was to evaluate the antimicrobial efficacy of ChloraLock with in vitro tests and its ability to reduce Staphylococcus aureus contamination of catheters in the external jugular veins of Yorkshire swine. ChloraLock significantly reduced the bacterial load in the in vitro tests by up to 6 log(10) colony-forming units (CFU) and by 3 to 4 log(10) CFU/lumen in vivo in a swine model with 0.9% NaCl catheter locks.
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spelling pubmed-58620072018-03-28 Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus aureus Colonization of Venous Catheters Kowalewska, Paulina M. Petrik, Shawn M. Di Fiore, Attilio E. Fox-Robichaud, Alison E. J Infus Nurs Features Vascular catheters are a major cause of nosocomial bloodstream infections. ChloraLock (ATTWILL Medical Solutions, Inc, West Jordan, UT, and ICU Medical, Inc, San Clemente, CA) is a novel antimicrobial device containing chlorhexidine digluconate (CHG) that is fitted onto a syringe and infuses CHG into the catheter lumen during locking. The objective of this study was to evaluate the antimicrobial efficacy of ChloraLock with in vitro tests and its ability to reduce Staphylococcus aureus contamination of catheters in the external jugular veins of Yorkshire swine. ChloraLock significantly reduced the bacterial load in the in vitro tests by up to 6 log(10) colony-forming units (CFU) and by 3 to 4 log(10) CFU/lumen in vivo in a swine model with 0.9% NaCl catheter locks. Wolters Kluwer Health, Inc. 2018-03 2018-03-14 /pmc/articles/PMC5862007/ /pubmed/29489705 http://dx.doi.org/10.1097/NAN.0000000000000267 Text en © 2018 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Infusion Nurses Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Features
Kowalewska, Paulina M.
Petrik, Shawn M.
Di Fiore, Attilio E.
Fox-Robichaud, Alison E.
Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus aureus Colonization of Venous Catheters
title Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus aureus Colonization of Venous Catheters
title_full Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus aureus Colonization of Venous Catheters
title_fullStr Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus aureus Colonization of Venous Catheters
title_full_unstemmed Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus aureus Colonization of Venous Catheters
title_short Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus aureus Colonization of Venous Catheters
title_sort antimicrobial efficacy of a new chlorhexidine-based device against staphylococcus aureus colonization of venous catheters
topic Features
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862007/
https://www.ncbi.nlm.nih.gov/pubmed/29489705
http://dx.doi.org/10.1097/NAN.0000000000000267
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