Cargando…
Autoimmune Diabetes Associated With Pembrolizumab: A Review of Published Case Reports
The utility of immunotherapy, such as pembrolizumab, is becoming essential in the treatment of certain cancers. Pembrolizumab works through binding of programmed cell death 1 receptor that blocks the binding of the programmed cell death ligand 1 and is commonly used in non-small cell lung cancer and...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862076/ https://www.ncbi.nlm.nih.gov/pubmed/29581809 http://dx.doi.org/10.14740/wjon1085w |
_version_ | 1783308165029298176 |
---|---|
author | Cheema, Anmol Makadia, Bhaktidevi Karwadia, Tejas Bajwa, Ravneet Hossain, Mohammad |
author_facet | Cheema, Anmol Makadia, Bhaktidevi Karwadia, Tejas Bajwa, Ravneet Hossain, Mohammad |
author_sort | Cheema, Anmol |
collection | PubMed |
description | The utility of immunotherapy, such as pembrolizumab, is becoming essential in the treatment of certain cancers. Pembrolizumab works through binding of programmed cell death 1 receptor that blocks the binding of the programmed cell death ligand 1 and is commonly used in non-small cell lung cancer and melanoma. Pembrolizumab has been reported to be associated with multiple adverse reactions such as pneumonitis, colitis, hepatitis, hypophysitis, hyperthyroidism, hypothyroidism, nephritis, and type 1 diabetes; however, pembrolizumab causing type 1 diabetes was only reported in 0.1% of the patients in clinical trials. A review of the literature generated 1,001 unique citations of which six reported cases of autoimmune diabetes associated with pembrolizumab were selected and compared. Review of the cases showed no sexual predilection and the average age of onset was 58 years old. The majority of the patients were treated for melanoma (5/6 cases), initially presented with diabetic ketoacidosis (4/6 cases), and had at one point taken ipilimumab (4/6 cases). There was no association found between the number of treatments received and the development of diabetes. With the increasing use of pembrolizumab in cancer treatment regular blood glucose monitoring during treatment, especially in patients who had also taken ipilimumab, may prevent the onset of this life-threatening complication. |
format | Online Article Text |
id | pubmed-5862076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58620762018-03-26 Autoimmune Diabetes Associated With Pembrolizumab: A Review of Published Case Reports Cheema, Anmol Makadia, Bhaktidevi Karwadia, Tejas Bajwa, Ravneet Hossain, Mohammad World J Oncol Review The utility of immunotherapy, such as pembrolizumab, is becoming essential in the treatment of certain cancers. Pembrolizumab works through binding of programmed cell death 1 receptor that blocks the binding of the programmed cell death ligand 1 and is commonly used in non-small cell lung cancer and melanoma. Pembrolizumab has been reported to be associated with multiple adverse reactions such as pneumonitis, colitis, hepatitis, hypophysitis, hyperthyroidism, hypothyroidism, nephritis, and type 1 diabetes; however, pembrolizumab causing type 1 diabetes was only reported in 0.1% of the patients in clinical trials. A review of the literature generated 1,001 unique citations of which six reported cases of autoimmune diabetes associated with pembrolizumab were selected and compared. Review of the cases showed no sexual predilection and the average age of onset was 58 years old. The majority of the patients were treated for melanoma (5/6 cases), initially presented with diabetic ketoacidosis (4/6 cases), and had at one point taken ipilimumab (4/6 cases). There was no association found between the number of treatments received and the development of diabetes. With the increasing use of pembrolizumab in cancer treatment regular blood glucose monitoring during treatment, especially in patients who had also taken ipilimumab, may prevent the onset of this life-threatening complication. Elmer Press 2018-02 2018-03-08 /pmc/articles/PMC5862076/ /pubmed/29581809 http://dx.doi.org/10.14740/wjon1085w Text en Copyright 2018, Cheema et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Cheema, Anmol Makadia, Bhaktidevi Karwadia, Tejas Bajwa, Ravneet Hossain, Mohammad Autoimmune Diabetes Associated With Pembrolizumab: A Review of Published Case Reports |
title | Autoimmune Diabetes Associated With Pembrolizumab: A Review of Published Case Reports |
title_full | Autoimmune Diabetes Associated With Pembrolizumab: A Review of Published Case Reports |
title_fullStr | Autoimmune Diabetes Associated With Pembrolizumab: A Review of Published Case Reports |
title_full_unstemmed | Autoimmune Diabetes Associated With Pembrolizumab: A Review of Published Case Reports |
title_short | Autoimmune Diabetes Associated With Pembrolizumab: A Review of Published Case Reports |
title_sort | autoimmune diabetes associated with pembrolizumab: a review of published case reports |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862076/ https://www.ncbi.nlm.nih.gov/pubmed/29581809 http://dx.doi.org/10.14740/wjon1085w |
work_keys_str_mv | AT cheemaanmol autoimmunediabetesassociatedwithpembrolizumabareviewofpublishedcasereports AT makadiabhaktidevi autoimmunediabetesassociatedwithpembrolizumabareviewofpublishedcasereports AT karwadiatejas autoimmunediabetesassociatedwithpembrolizumabareviewofpublishedcasereports AT bajwaravneet autoimmunediabetesassociatedwithpembrolizumabareviewofpublishedcasereports AT hossainmohammad autoimmunediabetesassociatedwithpembrolizumabareviewofpublishedcasereports |