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Early preterm nutrition and the urinary metabolome in young adult life: follow-up of a randomised controlled trial
OBJECTIVE: We aimed to test the hypothesis that early diet programmes the metabolic profile of young adults born preterm. DESIGN: We analysed banked urine samples obtained at a 20-year follow-up visit from adults that had participated as neonates in controlled trials involving randomisation within 4...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862206/ https://www.ncbi.nlm.nih.gov/pubmed/29637175 http://dx.doi.org/10.1136/bmjpo-2017-000192 |
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author | Parkinson, James R C Wijeyesekera, Anisha D Hyde, Matthew J Singhal, Atul Lucas, Alan Holmes, Elaine Modi, Neena |
author_facet | Parkinson, James R C Wijeyesekera, Anisha D Hyde, Matthew J Singhal, Atul Lucas, Alan Holmes, Elaine Modi, Neena |
author_sort | Parkinson, James R C |
collection | PubMed |
description | OBJECTIVE: We aimed to test the hypothesis that early diet programmes the metabolic profile of young adults born preterm. DESIGN: We analysed banked urine samples obtained at a 20-year follow-up visit from adults that had participated as neonates in controlled trials involving randomisation within 48 hours of birth to feeds of preterm formula (PTF), banked breast milk (BBM) or term formula (TF) for 1 month postnatally. MAIN OUTCOME MEASURES: We performed proton nuclear magnetic resonance spectroscopy, analysing spectra by dietary group and sex. Orthogonal projections to latent structure discriminant analyses was used to model class differences and identify metabolites contributing to the differences between groups. Additionally, spectra were correlated with birth weight, gestational age and weight z score at 2 weeks of age. RESULTS: Of the original number of 926 trial participants, urine samples were available from 197 (21%) healthy young adults (42% men) born preterm (mean 30.7±2.8 weeks) and randomised to BBM (n=55; 28 men), TF (n=48; 14 men) and PTF (n=93; 40 men). We found no significant differences in urinary spectra between dietary groups including when stratified by sex. Correlation analysis revealed a weak association between metabolic profile and gestational age that was lost on controlling for ethanol excretion. CONCLUSIONS: We found no evidence that dietary exposures in the neonatal period influence the metabolic phenotype in young adult life. |
format | Online Article Text |
id | pubmed-5862206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-58622062018-04-10 Early preterm nutrition and the urinary metabolome in young adult life: follow-up of a randomised controlled trial Parkinson, James R C Wijeyesekera, Anisha D Hyde, Matthew J Singhal, Atul Lucas, Alan Holmes, Elaine Modi, Neena BMJ Paediatr Open Original Article OBJECTIVE: We aimed to test the hypothesis that early diet programmes the metabolic profile of young adults born preterm. DESIGN: We analysed banked urine samples obtained at a 20-year follow-up visit from adults that had participated as neonates in controlled trials involving randomisation within 48 hours of birth to feeds of preterm formula (PTF), banked breast milk (BBM) or term formula (TF) for 1 month postnatally. MAIN OUTCOME MEASURES: We performed proton nuclear magnetic resonance spectroscopy, analysing spectra by dietary group and sex. Orthogonal projections to latent structure discriminant analyses was used to model class differences and identify metabolites contributing to the differences between groups. Additionally, spectra were correlated with birth weight, gestational age and weight z score at 2 weeks of age. RESULTS: Of the original number of 926 trial participants, urine samples were available from 197 (21%) healthy young adults (42% men) born preterm (mean 30.7±2.8 weeks) and randomised to BBM (n=55; 28 men), TF (n=48; 14 men) and PTF (n=93; 40 men). We found no significant differences in urinary spectra between dietary groups including when stratified by sex. Correlation analysis revealed a weak association between metabolic profile and gestational age that was lost on controlling for ethanol excretion. CONCLUSIONS: We found no evidence that dietary exposures in the neonatal period influence the metabolic phenotype in young adult life. BMJ Publishing Group 2017-11-01 /pmc/articles/PMC5862206/ /pubmed/29637175 http://dx.doi.org/10.1136/bmjpo-2017-000192 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Original Article Parkinson, James R C Wijeyesekera, Anisha D Hyde, Matthew J Singhal, Atul Lucas, Alan Holmes, Elaine Modi, Neena Early preterm nutrition and the urinary metabolome in young adult life: follow-up of a randomised controlled trial |
title | Early preterm nutrition and the urinary metabolome in young adult life: follow-up of a randomised controlled trial |
title_full | Early preterm nutrition and the urinary metabolome in young adult life: follow-up of a randomised controlled trial |
title_fullStr | Early preterm nutrition and the urinary metabolome in young adult life: follow-up of a randomised controlled trial |
title_full_unstemmed | Early preterm nutrition and the urinary metabolome in young adult life: follow-up of a randomised controlled trial |
title_short | Early preterm nutrition and the urinary metabolome in young adult life: follow-up of a randomised controlled trial |
title_sort | early preterm nutrition and the urinary metabolome in young adult life: follow-up of a randomised controlled trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862206/ https://www.ncbi.nlm.nih.gov/pubmed/29637175 http://dx.doi.org/10.1136/bmjpo-2017-000192 |
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