Cargando…

Induction of non-apoptotic programmed cell death by oncogenic RAS in human epithelial cells and its suppression by MYC overexpression

Oncogenic mutations of RAS genes, found in about 30% of human cancers, are considered to play important roles in cancer development. However, oncogenic RAS can also induce senescence in mouse and human normal fibroblasts. In some cell lines, oncogenic RAS has been reported to induce non-apoptotic pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dendo, Kasumi, Yugawa, Takashi, Nakahara, Tomomi, Ohno, Shin-ichi, Goshima, Naoki, Arakawa, Hirofumi, Kiyono, Tohru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Carcinogenesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862353/ https://www.ncbi.nlm.nih.gov/pubmed/29106503 http://dx.doi.org/10.1093/carcin/bgx124

Ejemplares similares

Oncogenic mutation in RAS‐RAF axis leads to increased expression of GREB1, resulting in tumor proliferation in colorectal cancer
por: Kochi, Masatoshi, et al.
Publicado: (2020)

Targeting RNA helicase DHX33 blocks Ras‐driven lung tumorigenesis in vivo
por: Wang, Xingshun, et al.
Publicado: (2020)

Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice
por: Nishio, Miki, et al.
Publicado: (2020)

Ribose-5-phosphate isomerase A overexpression promotes liver cancer development in transgenic zebrafish via activation of ERK and β-catenin pathways
por: Chou, Yu-Ting, et al.
Publicado: (2019)

Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice
por: Hirohashi, Kenshiro, et al.
Publicado: (2020)

DRP1 promotes lactate utilization in KRAS‐mutant non‐small‐cell lung cancer cells
por: Hu, Mangze, et al.
Publicado: (2020)

Cell line-based xenograft mouse model of paediatric glioma stem cells mirrors the clinical course of the patient
por: Larsson, Susanna, et al.
Publicado: (2018)

An Ex-Vivo Culture System of Ovarian Cancer Faithfully Recapitulating the Pathological Features of Primary Tumors
por: Ghani, Farhana Ishrat, et al.
Publicado: (2019)

AFF4 promotes tumorigenesis and tumor-initiation capacity of head and neck squamous cell carcinoma cells by regulating SOX2
por: Deng, Peng, et al.
Publicado: (2018)

Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells
por: Thakur, Basant Kumar, et al.
Publicado: (2013)

Extra-virgin olive oil contains a metabolo-epigenetic inhibitor of cancer stem cells
por: Corominas-Faja, Bruna, et al.
Publicado: (2018)

The transformics assay: first steps for the development of an integrated approach to investigate the malignant cell transformation in vitro
por: Mascolo, Maria Grazia, et al.
Publicado: (2018)

MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma
por: Wang, Wen, et al.
Publicado: (2012)

Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice
por: Lakritz, Jessica R, et al.
Publicado: (2014)

DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3
por: Zhang, Xue, et al.
Publicado: (2020)

Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women
por: Goodson, William H., et al.
Publicado: (2011)

Loss of PPARγ expression in mammary secretory epithelial cells creates a pro-breast tumorigenic environment
por: Apostoli, Anthony J, et al.
Publicado: (2014)

Eomes promotes esophageal carcinoma progression by recruiting Treg cells through the CCL20‐CCR6 pathway
por: Lian, Jingyao, et al.
Publicado: (2020)

Prolonged unfolded protein reaction is involved in the induction of chronic myeloid leukemia cell death upon oprozomib treatment
por: Wang, Fang, et al.
Publicado: (2020)

Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells
por: Kitchen-Goosen, Susan M, et al.
Publicado: (2022)

Expulsion of micronuclei containing amplified genes contributes to a decrease in double minute chromosomes from malignant tumor cells
por: Ji, Wei, et al.
Publicado: (2014)

Knockdown of ISOC1 inhibits the proliferation and migration and induces the apoptosis of colon cancer cells through the AKT/GSK-3β pathway
por: Gao, Bo, et al.
Publicado: (2020)

Lapatinib-induced annexin A6 upregulation as an adaptive response of triple-negative breast cancer cells to EGFR tyrosine kinase inhibitors
por: Widatalla, Sarrah E, et al.
Publicado: (2019)

Induction of mismatch repair deficiency, compromised DNA damage signaling and compound hypermutagenesis by a dietary mutagen in a cell-based model for Lynch syndrome
por: Ijsselsteijn, Robbert, et al.
Publicado: (2021)

Inactivation of homeodomain‐interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53‐dependent E‐cadherin expression
por: Zheng, Xueqing, et al.
Publicado: (2020)

LncRNA GAS5 regulates the Wnt/β-catenin pathway through the miR-18a-5p/AXIN2/GSK3β axis to inhibit the proliferation and migration of bladder cancer cells
por: Zhang, Ze, et al.
Publicado: (2022)

Manual de métodos para la identificación de mutágenos y carcinógenos químicos ambientales
Publicado: (1980)

RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
por: Turovskaya, Olga, et al.
Publicado: (2008)

CpG methylation in exon 1 of transcription factor 4 increases with age in normal gastric mucosa and is associated with gene silencing in intestinal-type gastric cancers
por: Kim, Seung-Kyoon, et al.
Publicado: (2008)

Constitutive expression of human keratin 14 gene in mouse lung induces premalignant lesions and squamous differentiation
por: Habib Dakir, EL, et al.
Publicado: (2008)

Predominant modifier of extreme liver cancer susceptibility in C57BR/cdJ female mice localized to 6 Mb on chromosome 17
por: Peychal, Stephanie E.-M., et al.
Publicado: (2009)

Epigenetic repression of E-cadherin by human papillomavirus 16 E7 protein
por: Laurson, Joanna, et al.
Publicado: (2010)

Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse
por: Matsumoto, Kojiro, et al.
Publicado: (2010)

Association between hMLH1 hypermethylation and JC virus (JCV) infection in human colorectal cancer (CRC)
por: Vilkin, Alex, et al.
Publicado: (2010)

Interaction of SET domains with histones and nucleic acid structures in active chromatin
por: Krajewski, Wladyslaw A., et al.
Publicado: (2011)

Monocyclic aromatic amines as potential human carcinogens: old is new again
por: Skipper, Paul L., et al.
Publicado: (2010)

Both base excision repair and O(6)-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis
por: Wirtz, Stefan, et al.
Publicado: (2010)

De novo-generated small palindromes are characteristic of amplicon boundary junction of double minutes
por: Zhu, Jing, et al.
Publicado: (2013)

Areca nut exposure increases secretion of tumor‐promoting cytokines in gingival fibroblasts that trigger DNA damage in oral keratinocytes
por: Illeperuma, Rasika P., et al.
Publicado: (2015)

Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3
por: Fetahu, Irfete S, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_9eap19rq91rrj6e8i8dds20c9j