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Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness
Hyaluronan is abundant in the extracellular matrix of many desmoplastic tumors and determines in large part the tumor biochemical and mechanical microenvironment. Additionally, it has been identified as one of the major physiological barriers to the effective delivery of drugs to solid tumors and it...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862434/ https://www.ncbi.nlm.nih.gov/pubmed/29561855 http://dx.doi.org/10.1371/journal.pone.0193801 |