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Salient experiences are represented by unique transcriptional signatures in the mouse brain
It is well established that inducible transcription is essential for the consolidation of salient experiences into long-term memory. However, whether inducible transcription relays information about the identity and affective attributes of the experience being encoded, has not been explored. To this...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862526/ https://www.ncbi.nlm.nih.gov/pubmed/29412137 http://dx.doi.org/10.7554/eLife.31220 |
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author | Mukherjee, Diptendu Ignatowska-Jankowska, Bogna Marta Itskovits, Eyal Gonzales, Ben Jerry Turm, Hagit Izakson, Liz Haritan, Doron Bleistein, Noa Cohen, Chen Amit, Ido Shay, Tal Grueter, Brad Zaslaver, Alon Citri, Ami |
author_facet | Mukherjee, Diptendu Ignatowska-Jankowska, Bogna Marta Itskovits, Eyal Gonzales, Ben Jerry Turm, Hagit Izakson, Liz Haritan, Doron Bleistein, Noa Cohen, Chen Amit, Ido Shay, Tal Grueter, Brad Zaslaver, Alon Citri, Ami |
author_sort | Mukherjee, Diptendu |
collection | PubMed |
description | It is well established that inducible transcription is essential for the consolidation of salient experiences into long-term memory. However, whether inducible transcription relays information about the identity and affective attributes of the experience being encoded, has not been explored. To this end, we analyzed transcription induced by a variety of rewarding and aversive experiences, across multiple brain regions. Our results describe the existence of robust transcriptional signatures uniquely representing distinct experiences, enabling near-perfect decoding of recent experiences. Furthermore, experiences with shared attributes display commonalities in their transcriptional signatures, exemplified in the representation of valence, habituation and reinforcement. This study introduces the concept of a neural transcriptional code, which represents the encoding of experiences in the mouse brain. This code is comprised of distinct transcriptional signatures that correlate to attributes of the experiences that are being committed to long-term memory. |
format | Online Article Text |
id | pubmed-5862526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-58625262018-03-22 Salient experiences are represented by unique transcriptional signatures in the mouse brain Mukherjee, Diptendu Ignatowska-Jankowska, Bogna Marta Itskovits, Eyal Gonzales, Ben Jerry Turm, Hagit Izakson, Liz Haritan, Doron Bleistein, Noa Cohen, Chen Amit, Ido Shay, Tal Grueter, Brad Zaslaver, Alon Citri, Ami eLife Neuroscience It is well established that inducible transcription is essential for the consolidation of salient experiences into long-term memory. However, whether inducible transcription relays information about the identity and affective attributes of the experience being encoded, has not been explored. To this end, we analyzed transcription induced by a variety of rewarding and aversive experiences, across multiple brain regions. Our results describe the existence of robust transcriptional signatures uniquely representing distinct experiences, enabling near-perfect decoding of recent experiences. Furthermore, experiences with shared attributes display commonalities in their transcriptional signatures, exemplified in the representation of valence, habituation and reinforcement. This study introduces the concept of a neural transcriptional code, which represents the encoding of experiences in the mouse brain. This code is comprised of distinct transcriptional signatures that correlate to attributes of the experiences that are being committed to long-term memory. eLife Sciences Publications, Ltd 2018-02-07 /pmc/articles/PMC5862526/ /pubmed/29412137 http://dx.doi.org/10.7554/eLife.31220 Text en © 2018, Mukherjee et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Mukherjee, Diptendu Ignatowska-Jankowska, Bogna Marta Itskovits, Eyal Gonzales, Ben Jerry Turm, Hagit Izakson, Liz Haritan, Doron Bleistein, Noa Cohen, Chen Amit, Ido Shay, Tal Grueter, Brad Zaslaver, Alon Citri, Ami Salient experiences are represented by unique transcriptional signatures in the mouse brain |
title | Salient experiences are represented by unique transcriptional signatures in the mouse brain |
title_full | Salient experiences are represented by unique transcriptional signatures in the mouse brain |
title_fullStr | Salient experiences are represented by unique transcriptional signatures in the mouse brain |
title_full_unstemmed | Salient experiences are represented by unique transcriptional signatures in the mouse brain |
title_short | Salient experiences are represented by unique transcriptional signatures in the mouse brain |
title_sort | salient experiences are represented by unique transcriptional signatures in the mouse brain |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862526/ https://www.ncbi.nlm.nih.gov/pubmed/29412137 http://dx.doi.org/10.7554/eLife.31220 |
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