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The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma

Previous studies showed that the low expressions of chromodomain-helicase-DNA-binding protein 5 (CHD5) were intensively associated with deteriorative biologic and clinical characteristics as well as outcomes in many tumors. The aim of this study is to determine whether CHD5 single nucleotide polymor...

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Autores principales: Zhu, Xiao, Kong, Qingming, Xie, Liwei, Chen, Zhihong, Li, Hongmei, Zhu, Zhu, Huang, Yongmei, Lan, Feifei, Luo, Haiqing, Zhan, Jingting, Ding, Hongrong, Lei, Jinli, Xiao, Qin, Fu, Weiming, Fan, Wenguo, Zhang, Jinfang, Luo, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862573/
https://www.ncbi.nlm.nih.gov/pubmed/29568352
http://dx.doi.org/10.18632/oncotarget.23812
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author Zhu, Xiao
Kong, Qingming
Xie, Liwei
Chen, Zhihong
Li, Hongmei
Zhu, Zhu
Huang, Yongmei
Lan, Feifei
Luo, Haiqing
Zhan, Jingting
Ding, Hongrong
Lei, Jinli
Xiao, Qin
Fu, Weiming
Fan, Wenguo
Zhang, Jinfang
Luo, Hui
author_facet Zhu, Xiao
Kong, Qingming
Xie, Liwei
Chen, Zhihong
Li, Hongmei
Zhu, Zhu
Huang, Yongmei
Lan, Feifei
Luo, Haiqing
Zhan, Jingting
Ding, Hongrong
Lei, Jinli
Xiao, Qin
Fu, Weiming
Fan, Wenguo
Zhang, Jinfang
Luo, Hui
author_sort Zhu, Xiao
collection PubMed
description Previous studies showed that the low expressions of chromodomain-helicase-DNA-binding protein 5 (CHD5) were intensively associated with deteriorative biologic and clinical characteristics as well as outcomes in many tumors. The aim of this study is to determine whether CHD5 single nucleotide polymorphisms (SNPs) contribute to the prognosis of hepatocellular carcima (HCC). The SNPs were selected according to their linkage disequilibrium (LD) in the targeted next-generation sequencing (NGS) and then genotyped with TaqMan probers. We revealed a rare haplotype AG in CHD5 (SNPs: rs12564469-rs9434711) was markedly associated with HCC prognosis. The univariate and multivariate regression analyses revealed the patients with worse overall survival time were those with tumor metastasis and haplotype AG, as well as cirrhosis, poor differentiation and IV-TNM stage. Based on the available public databases, we discovered the significant association between haplotype AG and CHD5 mRNA expressions only existed in Chinese. These data proposed that the potentially genetic haplotype might functionally contribute to HCC prognosis and CHD5 mRNA expressions.
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spelling pubmed-58625732018-03-22 The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma Zhu, Xiao Kong, Qingming Xie, Liwei Chen, Zhihong Li, Hongmei Zhu, Zhu Huang, Yongmei Lan, Feifei Luo, Haiqing Zhan, Jingting Ding, Hongrong Lei, Jinli Xiao, Qin Fu, Weiming Fan, Wenguo Zhang, Jinfang Luo, Hui Oncotarget Research Paper Previous studies showed that the low expressions of chromodomain-helicase-DNA-binding protein 5 (CHD5) were intensively associated with deteriorative biologic and clinical characteristics as well as outcomes in many tumors. The aim of this study is to determine whether CHD5 single nucleotide polymorphisms (SNPs) contribute to the prognosis of hepatocellular carcima (HCC). The SNPs were selected according to their linkage disequilibrium (LD) in the targeted next-generation sequencing (NGS) and then genotyped with TaqMan probers. We revealed a rare haplotype AG in CHD5 (SNPs: rs12564469-rs9434711) was markedly associated with HCC prognosis. The univariate and multivariate regression analyses revealed the patients with worse overall survival time were those with tumor metastasis and haplotype AG, as well as cirrhosis, poor differentiation and IV-TNM stage. Based on the available public databases, we discovered the significant association between haplotype AG and CHD5 mRNA expressions only existed in Chinese. These data proposed that the potentially genetic haplotype might functionally contribute to HCC prognosis and CHD5 mRNA expressions. Impact Journals LLC 2017-12-26 /pmc/articles/PMC5862573/ /pubmed/29568352 http://dx.doi.org/10.18632/oncotarget.23812 Text en Copyright: © 2018 Zhu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhu, Xiao
Kong, Qingming
Xie, Liwei
Chen, Zhihong
Li, Hongmei
Zhu, Zhu
Huang, Yongmei
Lan, Feifei
Luo, Haiqing
Zhan, Jingting
Ding, Hongrong
Lei, Jinli
Xiao, Qin
Fu, Weiming
Fan, Wenguo
Zhang, Jinfang
Luo, Hui
The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma
title The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma
title_full The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma
title_fullStr The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma
title_full_unstemmed The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma
title_short The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma
title_sort single-nucleotide polymorphisms in chd5 affect the prognosis of patients with hepatocellular carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862573/
https://www.ncbi.nlm.nih.gov/pubmed/29568352
http://dx.doi.org/10.18632/oncotarget.23812
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