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The new allosteric inhibitor asciminib is susceptible to resistance mediated by ABCB1 and ABCG2 overexpression in vitro

Asciminib (previously ABL001), which binds the myristate-binding pocket of the Bcr-Abl kinase domain, is in phase I clinical trials as monotherapy and in combination with imatinib, nilotinib and dasatinib for the treatment of patients with refractory CML or Ph+ ALL. Asciminib sensitivity was evaluat...

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Detalles Bibliográficos
Autores principales:	Eadie, Laura N., Saunders, Verity A., Branford, Susan, White, Deborah L., Hughes, Timothy P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862588/ https://www.ncbi.nlm.nih.gov/pubmed/29568367 http://dx.doi.org/10.18632/oncotarget.24393

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