Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer

MAP kinase interacting kinases (MNKs) modulate the function of oncogene eukaryotic initiation factor 4E (eIF4E) through phosphorylation, which is necessary for oncogenic transformation. MNK1 gives rise to two mRNAs and thus two MNK1 isoforms, named MNK1a and MNK1b. MNK1b, the splice variant of human...

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Detalles Bibliográficos
Autores principales: Pinto-Díez, Celia, García-Recio, Eva M., Pérez-Morgado, M. Isabel, García-Hernández, Marta, Sanz-Criado, Lara, Sacristán, Silvia, Toledo-Lobo, M. Val, Pérez-Mies, Belén, Esteban-Rodríguez, Isabel, Pascual, Alejandro, Garcia-Villanueva, Mercedes, Martínez-Jañez, Noelia, González, Víctor M., Martín, M. Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862594/
https://www.ncbi.nlm.nih.gov/pubmed/29568373
http://dx.doi.org/10.18632/oncotarget.24417

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