Cargando…
Persistent DNA strand breaks induce a CAF-like phenotype in normal fibroblasts
Cancer-associated fibroblasts (CAFs) are an emerging target for cancer therapy as they promote tumour growth and metastatic potential. However, CAF targeting is complicated by the lack of knowledge-based strategies aiming to selectively eliminate these cells. There is a growing body of evidence sugg...
Autores principales: | Legrand, Arnaud J., Poletto, Mattia, Pankova, Daniela, Clementi, Elena, Moore, John, Castro-Giner, Francesc, Ryan, Anderson J., O’Neill, Eric, Markkanen, Enni, Dianov, Grigory L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862606/ https://www.ncbi.nlm.nih.gov/pubmed/29568385 http://dx.doi.org/10.18632/oncotarget.24446 |
Ejemplares similares
-
DNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer Comorbidity and Beyond
por: Markkanen, Enni, et al.
Publicado: (2016) -
The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks
por: Loshchenova, Polina S, et al.
Publicado: (2020) -
p53 coordinates base excision repair to prevent genomic instability
por: Poletto, Mattia, et al.
Publicado: (2016) -
Sp1 phosphorylation by ATM downregulates BER and promotes cell elimination in response to persistent DNA damage
por: Fletcher, Sally C, et al.
Publicado: (2018) -
Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability
por: Markkanen, Enni, et al.
Publicado: (2015)