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Computational modeling suggests impaired interactions between NKX2.5 and GATA4 in individuals carrying a novel pathogenic D16N NKX2.5 mutation

NKX2.5, a homeobox containing gene, plays an important role in embryonic heart development and associated mutations are linked with various cardiac abnormalities. We sequenced the NKX2.5 gene in 100 congenital heart disease (CHD) patients and 200 controls. Our analysis revealed a total of 7 mutation...

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Detalles Bibliográficos
Autores principales:	Mattapally, Saidulu, Singh, Mrityunjay, Murthy, Kona Samba, Asthana, Shailendra, Banerjee, Sanjay K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862610/ https://www.ncbi.nlm.nih.gov/pubmed/29568389 http://dx.doi.org/10.18632/oncotarget.24459

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