A single digital droplet PCR assay to detect multiple KIT exon 11 mutations in tumor and plasma from patients with gastrointestinal stromal tumors

BACKGROUND: Gastrointestinal stromal tumors (GISTs) are characterized by oncogenic KIT mutations that cluster in two exon 11 hotspots. The aim of this study was to develop a single, sensitive, quantitative digital droplet PCR (ddPCR) assay for the detection of common exon 11 mutations in both GIST t...

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Detalles Bibliográficos
Autores principales: Boonstra, Pieter A., ter Elst, Arja, Tibbesma, Marco, Bosman, Lisette J., Mathijssen, Ron, Atrafi, Florence, van Coevorden, Frits, Steeghs, Neeltje, Farag, Sheima, Gelderblom, Hans, van der Graaf, Winette T.A., Desar, Ingrid M.E., Maier, Jacqueline, Overbosch, Jelle, Suurmeijer, Albert J.H., Gietema, Jourik, Schuuring, Ed, Reyners, Anna K.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862622/
https://www.ncbi.nlm.nih.gov/pubmed/29568401
http://dx.doi.org/10.18632/oncotarget.24493

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