Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity

We previously reported a functional humanized bispecific diabody (bsDb) that targeted EGFR and CD3 (hEx3-Db) and enhancement of its cytotoxicity by rearranging the domain order in the V domain. Here, we further dissected the effect of domain order in bsDbs on their cross-linking ability and binding...

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Detalles Bibliográficos
Autores principales: Asano, Ryutaro, Nagai, Keisuke, Makabe, Koki, Takahashi, Kento, Kumagai, Takashi, Kawaguchi, Hiroko, Ogata, Hiromi, Arai, Kyoko, Umetsu, Mitsuo, Kumagai, Izumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862623/
https://www.ncbi.nlm.nih.gov/pubmed/29568402
http://dx.doi.org/10.18632/oncotarget.24490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862623/
https://www.ncbi.nlm.nih.gov/pubmed/29568402
http://dx.doi.org/10.18632/oncotarget.24490

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