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Association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis

Obesity is one of the major risk factors of cancer. However, how body mass index (BMI) influences the prognosis of renal cell cancer (RCC) patient is unclear. In this work, we have performed a meta-analysis to elucidate the role of abnormal weight in RCC mortality and postoperative survival. Article...

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Autores principales: Zhang, Jiao, Chen, Qiang, Li, Zhan-Ming, Xu, Xu-Dong, Song, Ai-Fang, Wang, Li-Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862629/
https://www.ncbi.nlm.nih.gov/pubmed/29568408
http://dx.doi.org/10.18632/oncotarget.24210
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author Zhang, Jiao
Chen, Qiang
Li, Zhan-Ming
Xu, Xu-Dong
Song, Ai-Fang
Wang, Li-Shun
author_facet Zhang, Jiao
Chen, Qiang
Li, Zhan-Ming
Xu, Xu-Dong
Song, Ai-Fang
Wang, Li-Shun
author_sort Zhang, Jiao
collection PubMed
description Obesity is one of the major risk factors of cancer. However, how body mass index (BMI) influences the prognosis of renal cell cancer (RCC) patient is unclear. In this work, we have performed a meta-analysis to elucidate the role of abnormal weight in RCC mortality and postoperative survival. Articles related to BMI and RCC mortality as well as postoperative survival has been identified by searching PUBMED and ENBASE. Totally, 19 articles have been selected for this meta-analysis, 5 articles for RCC mortality and 14 for postoperative survival. Compared to normal weight, the estimated relative risks of RCC mortality are 0.71 (95% CI: 0.34–1.49), 1.19 (95% CI: 1.05–1.35) and 1.71 (95% CI: 1.27–2.00) respectively for the underweight, overweight and obesity patients. The risk of RCC mortality increase 5% for each 1 kg/m(2) increment of BMI. However, the estimated hazard ratios of cancer specific postoperative survival are 2.62 (95% CI: 1.67–4.11), 0.72 (95% CI: 0.63–0.83) and 0.66 (95% CI: 0.49–0.89) respectively for underweight, overweight and obesity RCC patients. The risk of hazard ratio decrease 5% for each 1 kg/m(2) increment of BMI. In addition, the hazard ratios of postoperative overall survival show a similar tendency. These results indicate an opposite association of BMI with mortality and postoperative survival in renal cell cancer patients.
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spelling pubmed-58626292018-03-22 Association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis Zhang, Jiao Chen, Qiang Li, Zhan-Ming Xu, Xu-Dong Song, Ai-Fang Wang, Li-Shun Oncotarget Meta-Analysis Obesity is one of the major risk factors of cancer. However, how body mass index (BMI) influences the prognosis of renal cell cancer (RCC) patient is unclear. In this work, we have performed a meta-analysis to elucidate the role of abnormal weight in RCC mortality and postoperative survival. Articles related to BMI and RCC mortality as well as postoperative survival has been identified by searching PUBMED and ENBASE. Totally, 19 articles have been selected for this meta-analysis, 5 articles for RCC mortality and 14 for postoperative survival. Compared to normal weight, the estimated relative risks of RCC mortality are 0.71 (95% CI: 0.34–1.49), 1.19 (95% CI: 1.05–1.35) and 1.71 (95% CI: 1.27–2.00) respectively for the underweight, overweight and obesity patients. The risk of RCC mortality increase 5% for each 1 kg/m(2) increment of BMI. However, the estimated hazard ratios of cancer specific postoperative survival are 2.62 (95% CI: 1.67–4.11), 0.72 (95% CI: 0.63–0.83) and 0.66 (95% CI: 0.49–0.89) respectively for underweight, overweight and obesity RCC patients. The risk of hazard ratio decrease 5% for each 1 kg/m(2) increment of BMI. In addition, the hazard ratios of postoperative overall survival show a similar tendency. These results indicate an opposite association of BMI with mortality and postoperative survival in renal cell cancer patients. Impact Journals LLC 2018-01-12 /pmc/articles/PMC5862629/ /pubmed/29568408 http://dx.doi.org/10.18632/oncotarget.24210 Text en Copyright: © 2018 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Meta-Analysis
Zhang, Jiao
Chen, Qiang
Li, Zhan-Ming
Xu, Xu-Dong
Song, Ai-Fang
Wang, Li-Shun
Association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis
title Association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis
title_full Association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis
title_fullStr Association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis
title_full_unstemmed Association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis
title_short Association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis
title_sort association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862629/
https://www.ncbi.nlm.nih.gov/pubmed/29568408
http://dx.doi.org/10.18632/oncotarget.24210
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