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Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome

BACKGROUND: Li-Fraumeni syndrome (LFS) is a cancer predisposition disorder characterized by germline mutations of the p53 tumor-suppressor gene. In response to DNA damage, p53 stimulates protective cellular processes including cell-cycle arrest and apoptosis to prevent aberrant cell proliferation. C...

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Detalles Bibliográficos
Autores principales:	Schuler, Nadine, Palm, Jan, Schmitz, Sabine, Lorat, Yvonne, Rübe, Claudia E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862648/ https://www.ncbi.nlm.nih.gov/pubmed/29594232 http://dx.doi.org/10.1016/j.ctro.2017.10.004

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